Literature summary for 1.14.16.2 extracted from

Martinez, A.; Haavik, J.; Flatmark, T.; Arrondo, J.L.; Muga, A.
Conformational properties and stability of tyrosine hydroxylase studied by infrared spectroscopy. Effect of iron/catecholamine binding and phosphorylation (1996), J. Biol. Chem., 271, 19737-19742.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activation by phosphorylation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Catecholamines	feedback inhibition, reversible by phosphorylation	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	Homo sapiens	first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine	3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	Homo sapiens	rate-limiting step in catecholamine biosynthesis	3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform 1 hTH1	-

Reaction

Reaction	Comment	Organism	Reaction ID
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine	secondary structure and conformation analysis of phosphorylated and unphosphorylated isoform hTH1	Homo sapiens	a
L-tyrosine + a 5,6,7,8-tetrahydropteridine + O2 = L-dopa + a 4a-hydroxy-5,6,7,8-tetrahydropteridine	phosphorylation site of hTH1 is Ser-40	Homo sapiens	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tyrosine + tetrahydrobiopterin + O2	-	Homo sapiens	3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O	3,4-dihydroxy-L-phenylalanine is identical with dopa	?
L-tyrosine + tetrahydrobiopterin + O2	first step in biosynthesis of catecholamines such as norepinephrine, epinephrine and dopamine	Homo sapiens	3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O	-	?
L-tyrosine + tetrahydrobiopterin + O2	rate-limiting step in catecholamine biosynthesis	Homo sapiens	3,4-dihydroxy-L-phenylalanine + dihydrobiopterin + H2O	-	?

Synonyms

Synonyms	Comment	Organism
TH	-	Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
additional information	-	thermal stability of hTH1 is increased by phosphorylation at Ser-40	Homo sapiens

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Release 2023.1 (January 2023)