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Literature summary for 1.14.16.1 extracted from

  • Calvo, A.C.; Pey, A.L.; Ying, M.; Loer, C.M.; Martinez, A.
    Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans (2008), FASEB J., 22, 3046-3058.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene pah-1, expression as maltose-binding protein fusion protein in Escherichia coli Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information gene pah-1 knockout mutant worms do not show an altered phenotype, but in combination with a second mutation of cuticle synthesis, the mutant worms lack a yellow pigment in the cuticle, and show stimulatory effect on superoxide dismutase, and severe cuticle defects, overview Caenorhabditis elegans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic analysis Caenorhabditis elegans
0.035
-
tetrahydrobiopterin
-
Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2 Caenorhabditis elegans mechanism and regulation of the enzyme, which is involved in synthesis of a melamin compound required for cuticle synthesis, overview L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q9XYQ5 wild-type strain N2 and mutant strains, gene pah-1
-

Purification (Commentary)

Purification (Comment) Organism
recombinant maltose-binding protein-PAH fusion protein from Escherichia coli, cleavage of the fusion protein by factor Xa, gel filtration Caenorhabditis elegans

Reaction

Reaction Comment Organism Reaction ID
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine molecular mechanism Caenorhabditis elegans

Source Tissue

Source Tissue Comment Organism Textmining
gravid adult
-
Caenorhabditis elegans
-
hypodermis enzyme expression Caenorhabditis elegans
-
larva
-
Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + tetrahydrobiopterin + O2
-
Caenorhabditis elegans L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?
L-phenylalanine + tetrahydrobiopterin + O2 mechanism and regulation of the enzyme, which is involved in synthesis of a melamin compound required for cuticle synthesis, overview Caenorhabditis elegans L-tyrosine + 4a-hydroxytetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
PAH
-
Caenorhabditis elegans
phenylalanine hydroxylase
-
Caenorhabditis elegans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Caenorhabditis elegans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin
-
Caenorhabditis elegans