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Literature summary for 1.14.16.1 extracted from

  • Teigen, K.; Jensen, V.R.; Martinez, A.
    The reaction mechanism of phenylalanine hydroxylase. - A question of coordination (2005), Pteridines, 16, 27-34.
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ active site bound, a non-heme iron Homo sapiens
Fe2+ active site bound, a non-heme iron Rattus norvegicus
Fe2+ active site bound, a non-heme iron Chromobacterium violaceum

Organism

Organism UniProt Comment Textmining
Chromobacterium violaceum
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine substrate and oxygen binding site, reaction mechanism, structure-function analysis Homo sapiens
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine substrate and oxygen binding site, reaction mechanism, structure-function analysis Rattus norvegicus
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine substrate and oxygen binding site, reaction mechanism, structure-function analysis Chromobacterium violaceum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2 substrate binding by His285, Trp326, Arg270, Ser349, and Trp278 Homo sapiens L-tyrosine + 4a-hydroxy-tetrahydrobiopterin
-
?
L-phenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus L-tyrosine + 4a-hydroxy-tetrahydrobiopterin
-
?
L-phenylalanine + tetrahydrobiopterin + O2
-
Chromobacterium violaceum L-tyrosine + 4a-hydroxy-tetrahydrobiopterin
-
?

Synonyms

Synonyms Comment Organism
PAH
-
Homo sapiens
PAH
-
Rattus norvegicus
PAH
-
Chromobacterium violaceum
phenylalanine hydroxylase
-
Homo sapiens
phenylalanine hydroxylase
-
Rattus norvegicus
phenylalanine hydroxylase
-
Chromobacterium violaceum

Cofactor

Cofactor Comment Organism Structure
tetrahydrobiopterin dependent on Homo sapiens
tetrahydrobiopterin dependent on Rattus norvegicus
tetrahydrobiopterin dependent on Chromobacterium violaceum