Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | active site bound, a non-heme iron | Homo sapiens | |
Fe2+ | active site bound, a non-heme iron | Rattus norvegicus | |
Fe2+ | active site bound, a non-heme iron | Chromobacterium violaceum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Chromobacterium violaceum | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | substrate and oxygen binding site, reaction mechanism, structure-function analysis | Homo sapiens | |
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | substrate and oxygen binding site, reaction mechanism, structure-function analysis | Rattus norvegicus | |
L-phenylalanine + a 5,6,7,8-tetrahydropteridine + O2 = L-tyrosine + a 4a-hydroxy-5,6,7,8-tetrahydropteridine | substrate and oxygen binding site, reaction mechanism, structure-function analysis | Chromobacterium violaceum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2 | substrate binding by His285, Trp326, Arg270, Ser349, and Trp278 | Homo sapiens | L-tyrosine + 4a-hydroxy-tetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | L-tyrosine + 4a-hydroxy-tetrahydrobiopterin | - |
? | |
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Chromobacterium violaceum | L-tyrosine + 4a-hydroxy-tetrahydrobiopterin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAH | - |
Homo sapiens |
PAH | - |
Rattus norvegicus |
PAH | - |
Chromobacterium violaceum |
phenylalanine hydroxylase | - |
Homo sapiens |
phenylalanine hydroxylase | - |
Rattus norvegicus |
phenylalanine hydroxylase | - |
Chromobacterium violaceum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | dependent on | Homo sapiens | |
tetrahydrobiopterin | dependent on | Rattus norvegicus | |
tetrahydrobiopterin | dependent on | Chromobacterium violaceum |