Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | 2 mM, 80% inhibition | Rattus norvegicus | |
ascorbate | 2 mM, 78% inhibition | Rattus norvegicus | |
dithiothreitol | 2 mM, 94% inhibition, dithiothreitol induces the dissociation of iron from the enzyme, catalase and phenylalanine partially protect from inhibition | Rattus norvegicus | |
L-cysteine | 2 mM, 42% inhibition | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Iron | 1 iron atom per subunit, fully active enzyme has non-heme high-spin ferric iron coordinated at the active site | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + tetrahydrobiopterin + O2 | - |
Rattus norvegicus | L-tyrosine + dihydrobiopterin + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Rattus norvegicus |