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Literature summary for 1.14.16.1 extracted from

  • Kaufman, S.
    Phenylalanine 4-monooxygenase from rat liver (1987), Methods Enzymol., 142, 3-17.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
lysolecithin
-
Rattus norvegicus
additional information
-
Rattus norvegicus
Phospholipids activate Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,2'-dipyridine
-
Rattus norvegicus
8-hydroxyquinoline
-
Rattus norvegicus
catechol
-
Rattus norvegicus
diethyldithiocarbamate
-
Rattus norvegicus
Dopa
-
Rattus norvegicus
dopamine
-
Rattus norvegicus
halogenated phenylalanine moderate Rattus norvegicus
additional information not inhibited by EDTA Rattus norvegicus
norepinephrine
-
Rattus norvegicus
o-phenanthroline
-
Rattus norvegicus
S-methyl-L-cysteine 6 mM, 55% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002 0.004 tetrahydrobiopterin
-
Rattus norvegicus
0.05 0.06 6,7-dimethyltetrahydropterin
-
Rattus norvegicus
0.2
-
phenylalanine cofactor tetrahydrobiopterin Rattus norvegicus
0.47
-
thienylalanine native enzyme Rattus norvegicus
0.47
-
thienylalanine native enzyme, cofactor tetrahydrobiopterin Rattus norvegicus
1.3
-
phenylalanine cofactor 6,7-dimethyltetrahydrobiopterin Rattus norvegicus
1.7
-
thienylalanine cofactor tetrahydrobiopterin, lysolecithin activated enzyme Rattus norvegicus
1.7
-
thienylalanine lysolecithin-activated enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron iron-protein Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000 55000 monomeric form, enzyme exists as monomer, dimer and tetramer Rattus norvegicus
100000 110000 dimeric form, enzyme exists as monomer, dimer and tetramer Rattus norvegicus
200000 210000 tetrameric species accounts for 78% of the total enzyme, enzyme exists as monomer, dimer and tetramer Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine + (6R)-tetrahydrobiopterin + O2 Rattus norvegicus in mammals rate-limiting step in complete catabolism of phenylalanine to CO2 and water L-tyrosine + (6R)-dihydrobiopterin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.59
-
-
Rattus norvegicus

Storage Stability

Storage Stability Organism
-80°C, 1 year, 30% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-fluorophenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
3-fluorophenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
3-phenylserine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
4-chlorophenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
4-fluorophenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
beta-2-thienylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
L-methionine + tetrahydrobiopterin + O2 lysolecithin activated enzyme Rattus norvegicus ?
-
?
L-norleucine + tetrahydrobiopterin + O2 lysolecithin activated enzyme Rattus norvegicus ?
-
?
L-phenylalanine + (6R)-tetrahydrobiopterin + O2 in mammals rate-limiting step in complete catabolism of phenylalanine to CO2 and water Rattus norvegicus L-tyrosine + (6R)-dihydrobiopterin + H2O
-
?
L-phenylalanine + tetrahydrobiopterin + O2 additional electron donors: 6-methylpterin, 6,7-dimethyltetrahydropterin Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O 4-alpha-carbinolamine is the first free pterin product formed ?
L-phenylalanine + tetrahydrobiopterin + O2 specificity is quantitatively altered when the enzyme is activated by lysolecithin Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O 4-alpha-carbinolamine is the first free pterin product formed ?
L-phenylalanine + tetrahydrobiopterin + O2 additional electron donors: 6-methyltetrahydropterin, 7-methylpterin, and 2,4,5-triamino-6-hydroxypyrimidine Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O 4-alpha-carbinolamine is the first free pterin product formed ?
L-phenylalanine + tetrahydrobiopterin + O2 low activity with tetrahydrobiopterin can be selectively increased by a wide variety of reversible and irreversible modificators of the enzyme, e.g. interaction with phospholipids Rattus norvegicus L-tyrosine + dihydrobiopterin + H2O 4-alpha-carbinolamine is the first free pterin product formed ?
L-tryptophan + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
m-tyrosine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
p-methylphenylalanine + tetrahydrobiopterin + O2
-
Rattus norvegicus ?
-
?
S-methyl-L-cysteine + tetrahydrobiopterin + O2 lysolecithin activated enzyme Rattus norvegicus ?
-
?
thienylalanine + tetrahydrobiopterin
-
Rattus norvegicus ?
-
r

Subunits

Subunits Comment Organism
dimer enzyme exists as monomer, dimer and tetramer Rattus norvegicus
monomer enzyme exists as monomer, dimer and tetramer Rattus norvegicus
tetramer enzyme exists as monomer, dimer and tetramer Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
additional information artificial cofactors: 6-methyltetrahydropterin, 6,7-dimethyltetrahydropterin Rattus norvegicus
additional information artificial cofactor: 2,4,5-triamino-6-hydroxypyrimidine Rattus norvegicus
additional information artificial cofactors: 6-methyltetrahydropterin, 7-methylpterin Rattus norvegicus
tetrahydrobiopterin
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
catechol
-
Rattus norvegicus