Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Rattus norvegicus | 5743 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 | Rattus norvegicus | - |
pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O | - |
? | |
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 | Rattus norvegicus Wistar | - |
pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O | - |
? | |
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 | Rattus norvegicus | - |
(20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 | Rattus norvegicus Wistar | - |
(20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
cholesterol + 2 reduced adrenodoxin + O2 | Rattus norvegicus | - |
(22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
cholesterol + 2 reduced adrenodoxin + O2 | Rattus norvegicus Wistar | - |
(22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
cholesterol + 6 reduced adrenodoxin + 3 O2 | Rattus norvegicus | overall reaction | pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O | - |
? | |
cholesterol + 6 reduced adrenodoxin + 3 O2 | Rattus norvegicus Wistar | overall reaction | pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Wistar | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially by purification of mitochondrial inner membranes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | renal cortex and medulla, distal convoluted tubule, and thick ascending limb of Henle's loop. The enzyme expression is higher in medulla than in cortex | Rattus norvegicus | - |
additional information | Immunohistochemical localization analysis | Rattus norvegicus | - |
renal cortex | - |
Rattus norvegicus | - |
renal medulla | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 | - |
Rattus norvegicus | pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O | - |
? | |
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 | - |
Rattus norvegicus Wistar | pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O | - |
? | |
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 | - |
Rattus norvegicus | (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 | - |
Rattus norvegicus Wistar | (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
cholesterol + 2 reduced adrenodoxin + O2 | - |
Rattus norvegicus | (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
cholesterol + 2 reduced adrenodoxin + O2 | - |
Rattus norvegicus Wistar | (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O | - |
? | |
cholesterol + 6 reduced adrenodoxin + 3 O2 | overall reaction | Rattus norvegicus | pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O | - |
? | |
cholesterol + 6 reduced adrenodoxin + 3 O2 | overall reaction | Rattus norvegicus Wistar | pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP11A1 | - |
Rattus norvegicus |
cytochrome P450 side chain cleavage enzyme | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adrenodoxin | - |
Rattus norvegicus | |
cytochrome P450 | - |
Rattus norvegicus |