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Literature summary for 1.14.15.6 extracted from

  • Pagotto, M.; Roldan, M.; Pagotto, R.; Lugano, M.; Pisani, G.; Rogic, G.; Molinas, S.; Trumper, L.; Pignataro, O.; Monasterolo, L.
    Localization and functional activity of cytochrome P450 side chain cleavage enzyme (CYP11A1) in the adult rat kidney (2011), Mol. Cell. Endocrinol., 332, 253-260.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
Rattus norvegicus 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus
-
pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
?
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus Wistar
-
pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
?
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus
-
(20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus Wistar
-
(20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus
-
(22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
cholesterol + 2 reduced adrenodoxin + O2 Rattus norvegicus Wistar
-
(22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
cholesterol + 6 reduced adrenodoxin + 3 O2 Rattus norvegicus overall reaction pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
?
cholesterol + 6 reduced adrenodoxin + 3 O2 Rattus norvegicus Wistar overall reaction pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Wistar
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially by purification of mitochondrial inner membranes Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney renal cortex and medulla, distal convoluted tubule, and thick ascending limb of Henle's loop. The enzyme expression is higher in medulla than in cortex Rattus norvegicus
-
additional information Immunohistochemical localization analysis Rattus norvegicus
-
renal cortex
-
Rattus norvegicus
-
renal medulla
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2
-
Rattus norvegicus pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
?
(20R,22R)-20,22-dihydroxy-cholesterol + 2 reduced adrenodoxin + O2
-
Rattus norvegicus Wistar pregnenolone + 4-methylpentanal + 2 oxidized adrenodoxin + 2 H2O
-
?
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2
-
Rattus norvegicus (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
(22R)-22-hydroxycholesterol + 2 reduced adrenodoxin + O2
-
Rattus norvegicus Wistar (20R,22R)-20,22-dihydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
cholesterol + 2 reduced adrenodoxin + O2
-
Rattus norvegicus (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
cholesterol + 2 reduced adrenodoxin + O2
-
Rattus norvegicus Wistar (22R)-22-hydroxycholesterol + 2 oxidized adrenodoxin + H2O
-
?
cholesterol + 6 reduced adrenodoxin + 3 O2 overall reaction Rattus norvegicus pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
?
cholesterol + 6 reduced adrenodoxin + 3 O2 overall reaction Rattus norvegicus Wistar pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O
-
?

Synonyms

Synonyms Comment Organism
CYP11A1
-
Rattus norvegicus
cytochrome P450 side chain cleavage enzyme
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Rattus norvegicus
cytochrome P450
-
Rattus norvegicus