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Literature summary for 1.14.15.6 extracted from
- Cloning and characterization of a cDNA encoding cholesterol side-chain cleavage cytochrome P450 (CYP11A1): tissue-distribution and changes in the transcript abundance in ovarian tissue of Japanese eel, Anguilla japonica, during artificially induced sexual development (2006), J. Steroid Biochem. Mol. Biol., 99, 121-128.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | enzyme induction by gonadotropic stimuli, e.g. artificially by a salmon piuitary homogenate, in ovary | Anguilla japonica |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene CYP11A1, DNA and amino acid sequence determination and analysis, expression pattern analysis, functional expression in COS-7 cells | Anguilla japonica |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | heme iron | Anguilla japonica |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Anguilla japonica | Q4KYY5 | Japanese eel, gene CYP11A1 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged CYP11A1 protein from Escherichia coli by nickel affinity chromatography | Anguilla japonica |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | head kidney | Anguilla japonica | - |
| additional information | tissue-specific expression pattern, overview | Anguilla japonica | - |
| ovary | enzyme expression increases throughout the ovarian development | Anguilla japonica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxycholesterol + O2 + reduced ferredoxin | - |
Anguilla japonica | pregnenolone + H2O + ferredoxin + 4-hydroxy-4-methylpentanal | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cholesterol side-chain cleavage cytochrome P450 | - |
Anguilla japonica |
| CYP11A1 | - |
Anguilla japonica |
| P450scc | - |
Anguilla japonica |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| Ferredoxin | - |
Anguilla japonica |
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