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Literature summary for 1.14.15.4 extracted from

  • Lajer, M.; Schjoedt, K.J.; Jacobsen, P.; Tarnow, L.; Parving, H.H.
    Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients (2006), Diabet. Med., 23, 675-680.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP11B2, located on chromosome 8q22, DAN and amino acid sequence determination, determination and analysis of the -344 polymorphism Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information the -344 T/C promoter polymorphism of CYP11B2 is involved in diabetic nephropathy, analysis of allele and genotype distributions and frequencies of the CYP11B2 -344T/C polymorphism Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
18-hydroxycorticosterone + reduced ferredoxin + O2 Homo sapiens aldosterone is one of the main effectors of the renin–angiotensin–aldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure aldosterone + ferredoxin + H2O
-
?
additional information Homo sapiens -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
adult Danish Caucasian Type 1 diabetic patients with diabetic nephropathy
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
18-hydroxycorticosterone + reduced ferredoxin + O2
-
Homo sapiens aldosterone + ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced ferredoxin + O2 aldosterone is one of the main effectors of the renin–angiotensin–aldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure Homo sapiens aldosterone + ferredoxin + H2O
-
?
additional information -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Aldosterone synthase
-
Homo sapiens
CYP11B2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Ferredoxin
-
Homo sapiens