Cloned (Comment) | Organism |
---|---|
gene CYP11B2, located on chromosome 8q22, DAN and amino acid sequence determination, determination and analysis of the -344 polymorphism | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the -344 T/C promoter polymorphism of CYP11B2 is involved in diabetic nephropathy, analysis of allele and genotype distributions and frequencies of the CYP11B2 -344T/C polymorphism | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
18-hydroxycorticosterone + reduced ferredoxin + O2 | Homo sapiens | aldosterone is one of the main effectors of the reninangiotensinaldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure | aldosterone + ferredoxin + H2O | - |
? | |
additional information | Homo sapiens | -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
adult Danish Caucasian Type 1 diabetic patients with diabetic nephropathy | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
18-hydroxycorticosterone + reduced ferredoxin + O2 | - |
Homo sapiens | aldosterone + ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced ferredoxin + O2 | aldosterone is one of the main effectors of the reninangiotensinaldosterone system, RAAS, regulating salt and water homeostasis and thereby also blood pressure | Homo sapiens | aldosterone + ferredoxin + H2O | - |
? | |
additional information | -344T/C polymorphism is associated with a clinically relevant phenotype for diabetic nephropathy such as hypertension | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aldosterone synthase | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Ferredoxin | - |
Homo sapiens |