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Literature summary for 1.14.15.4 extracted from

  • Boon, W.C.; Roche, P.J.; Butkus, A.; McDougall, J.G.; Jeyaseelan, K.; Coghlan, J.P.
    Functional and expression analysis of ovine steroid 11beta-hydroxylase (cytochrome P 45011beta) (1997), Endocr. Res., 23, 325-347.
    View publication on PubMed
Search for more literature for 1.14.15.4

Cloned(Commentary)

Cloned (Comment) Organism
cDNA transfected into COS-7 cells simultaneously with bovine adrenodoxin cDNA expression plasmid Ovis aries

Protein Variants

Protein Variants Comment Organism
additional information all enzymes with aldosterone synthesis activity have a glycine residue at position 288, in nonaldosterone synthesising P45011beta it is valine or serine Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
additional information conversion of labelled steroid to labelled aldosterone is inhibited by the addition of an excess of the same unlabelled steroid Ovis aries

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion from zona fasciculata Ovis aries 5739
-
mitochondrion from zona reticularis Ovis aries 5739
-
mitochondrion from zona glomerulosa Ovis aries 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 Ovis aries 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 Ovis aries 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 Ovis aries 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis 18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 11beta-hydroxylation Ovis aries corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis Ovis aries corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis Ovis aries aldosterone + oxidized adrenal ferredoxin + H2O
-
 ?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
 Ovis aries aldosterone + oxidized adrenal ferredoxin + H2O 18-hydroxylation ?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
 Ovis aries aldosterone + oxidized adrenal ferredoxin + H2O aldosterone production exclusively in the zona glomerulosa ?
corticosterone + reduced adrenal ferredoxin + O2 18-hydroxylation Ovis aries 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O
-
 ?
corticosterone + reduced adrenal ferredoxin + O2 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis Ovis aries 18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O
-
 ?