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Literature summary for 1.14.15.3 extracted from
- Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases (2008), Biochem. Pharmacol., 75, 2263-2275.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | CYP4A may be a therapeutic target in the control of inflammatory, vascular, and liver diseases, as well as peroxisome disorders of fatty acid metabolism | Mus musculus |
| drug development | CYP4A may be a therapeutic target in the control of inflammatory, vascular, and liver diseases, as well as peroxisome disorders of fatty acid metabolism | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| baculovirus expressed human CYP4A11 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.228 | - |
arachidonic acid | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Homo sapiens | - |
| kidney | CYP4A11 is one of the major kidney CYP4 P450s | Homo sapiens | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonic acid + NAD(P)H + H+ + O2 | - |
Mus musculus | (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O | - |
? | |
| arachidonic acid + NAD(P)H + H+ + O2 | the rate of metabolism by CYPA11 P450 is 10-100fold less as compared to lauric acid | Homo sapiens | (5Z,8Z,11Z,14Z)-20-hydroxyeicosa-5,8,11,14-tetraenoic acid + NAD(P)+ + H2O | - |
? | |
| lauric acid + NAD(P)H + H+ + O2 | CYPA11 P450 efficiently and selectively omega-hydroxylates lauric acid | Homo sapiens | 12-hydroxydodecanoic acid + NAD(P)+ + H2O | - |
? | |
| additional information | CYP4A prefers to metabolize medium chain fatty acids (C10-C16) | Homo sapiens | ? | - |
? | |
| additional information | CYP4A prefers to metabolize medium chain fatty acids (C10C16) | Mus musculus | ? | - |
? | |
| palmitic acid + NAD(P)H + H+ + O2 | CYPA11 P450 shows less selectivity in the metabolism of palmitic acid where both omega and omega-1 products are produced | Homo sapiens | 16-hydroxyhexadecanoic acid + NAD(P)+ + H2O | - |
? | |
| stearic acid + NAD(P)H + H+ + O2 | - |
Homo sapiens | ? + NAD(P)+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP4 P450 | - |
Mus musculus |
| CYP4 P450 | - |
Homo sapiens |
| CYP4A | - |
Mus musculus |
| CYP4A | - |
Homo sapiens |
| CYP4A10 | - |
Mus musculus |
| CYP4A14 | - |
Mus musculus |
| CYPA11 P450 | - |
Homo sapiens |
| cytochrome P450 omega hydroxylase | - |
Mus musculus |
| cytochrome P450 omega hydroxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD(P)H | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | in humans, the CYP4A11 gene is not induced by peroxisome proliferators | down |
| Homo sapiens | CYP4A gene is altered in both lipid and inflammatory disorders, modest 2fold induction of the CYP4A11 gene by peroxisome proliferator in primary human hepatocytes | up |
| Mus musculus | induction of CYP4A genes by starvation (60-700fold), by peroxisome proliferators (30-70fold), ethanol, high fat diet (2.5-100fold), and in diabetes and steatohepatitis. Dramatic induction of both the mouse CYP4A10 and CYP4A14 genes in CYP2E1 knockout mice, which accounts for the increased reactive oxygen species that induce lipid peroxidation | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | several diseases are genetically linked to the expression of CYP4 gene polymorphic variants, which may link human susceptibility to diseases of lipid metabolism and the activation and resolution phases of inflammation | Homo sapiens |
| metabolism | CYP4A functions in liver fatty acid metabolism | Homo sapiens |
| metabolism | CYP4A functions in liver fatty acid metabolism. Increased expression of the CYP4A omega hydroxylase during steatohepatitis and their induction in animals fed a high fat diet suggest they may play a pivotal role in preventing lipotoxicity, and may be responsible for induction of oxidative stress and progression to steatohepatitis. Omega-hydroxylation of the CYP2C arachidonic acid metabolite epoxyeicosatrienonic acid to omega-hydroxylated eicosatrienoic acid can induce peroxisome proliferation in rodents | Mus musculus |
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