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Literature summary for 1.14.15.18 extracted from

  • Overbergh, L.; Stoffels, K.; Waer, M.; Verstuyf, A.; Bouillon, R.; Mathieu, C.
    Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction (2006), J. Clin. Endocrinol. Metab., 91, 3566-3574.
    View publication on PubMed
Search for more literature for 1.14.15.18

Activating Compound

Activating Compound Comment Organism Structure
additional information phorbol myristate acetate, lipopolysaccharide, and IFNgamma induce enzyme expression in monocytes, regulation, the induction essentially requires the JAK-STAT, NF-kappaB, and p38 MAPK pathways, chromatin remodeling is required for immune-mediated up-regulation of 1alpha-hydroxylase, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitory effects of the MEK inhibitor PD98059, p38 MAPK inhibitor SB203580, and JNK inhibitor SP600125 on the IFNgamma/PMA-induced or IFNgamma/LPS-induced 1alpha-hydroxylase mRNA expression in THP1 cells, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2 Homo sapiens substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15528
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-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Homo sapiens
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monocyte
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 Homo sapiens
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THP-1 cell monocytic cell line Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2
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 Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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 ?
25-hydroxyvitamin D + NADPH + O2 substrate activation by the rate-limiting enzyme 1alpha-hydroxylase in cells of the immune system under control of immune stimuli, such as interferon-gamma, in pathological situations, such as sarcoidosis, this can lead to systemic excess of 1,25(OH)2D3 and hypercalcemia Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
25-hydroxyvitamin D-1alpha-hydroxylase
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 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
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 Homo sapiens