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Literature summary for 1.14.15.18 extracted from

  • Matusiak, D.; Murillo, G.; Carroll, R.E.; Mehta, R.G.; Benya, R.V.
    Expression of vitamin D receptor and 25-hydroxyvitamin D3-1{alpha}-hydroxylase in normal and malignant human colon (2005), Cancer Epidemiol. Biomarkers Prev., 14, 2370-2376.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2 Homo sapiens bioactivation 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
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?
additional information Homo sapiens 25(OH)D3 therapy is useful for colorectal cancer chemoprevention but provitamin D is less likely to be useful for colorectal cancer chemotherapy, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
colon healthy and malignant, high expression level, 1alpha-hydroxylase is present at equal high levels in normal colonic epithelium as in ACFs, polyps, and colorectal cancer irrespective of tumor cell differentiation Homo sapiens
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epithelial cell colonic, healthy and malignant, high expression level Homo sapiens
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additional information both 1alpha-hydroxylase and vitaminD receptor levels are negligible in tumor cells metastasizing to regional lymph nodes Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2
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Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
?
25-hydroxyvitamin D + NADPH + O2 bioactivation Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
?
additional information 25(OH)D3 therapy is useful for colorectal cancer chemoprevention but provitamin D is less likely to be useful for colorectal cancer chemotherapy, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
25-hydroxyvitamin D3-1alpha-hydroxylase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
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Homo sapiens