Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | Homo sapiens | bioactivation | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
additional information | Homo sapiens | 25(OH)D3 therapy is useful for colorectal cancer chemoprevention but provitamin D is less likely to be useful for colorectal cancer chemotherapy, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | healthy and malignant, high expression level, 1alpha-hydroxylase is present at equal high levels in normal colonic epithelium as in ACFs, polyps, and colorectal cancer irrespective of tumor cell differentiation | Homo sapiens | - |
epithelial cell | colonic, healthy and malignant, high expression level | Homo sapiens | - |
additional information | both 1alpha-hydroxylase and vitaminD receptor levels are negligible in tumor cells metastasizing to regional lymph nodes | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
25-hydroxyvitamin D + NADPH + O2 | - |
Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
25-hydroxyvitamin D + NADPH + O2 | bioactivation | Homo sapiens | 1alpha,25-dihydroxyvitamin D + NADP+ + H2O | - |
? | |
additional information | 25(OH)D3 therapy is useful for colorectal cancer chemoprevention but provitamin D is less likely to be useful for colorectal cancer chemotherapy, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
25-hydroxyvitamin D3-1alpha-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |