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Literature summary for 1.14.15.16 extracted from
- 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D (2012), Arch. Biochem. Biophys., 523, 9-18.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | Rattus norvegicus | - |
1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? |  |
| 25-hydroxyvitamin D3 + NADPH + H+ + O2 | Rattus norvegicus | - |
1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Rattus norvegicus | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
| 25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Rattus norvegicus | 1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 25-hydroxyvitamin D-24-hydroxylase | - |
Rattus norvegicus |
| CYP24A1 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | natural inactivating mutations of CYP24A1 cause the genetic disease idiopathic infantile hypercalcemia | Rattus norvegicus |
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Release 2023.1 (January 2023)
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