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Literature summary for 1.14.15.16 extracted from

  • Tenenhouse, H.S.; Jones, G.
    Effect of the X-linked Hyp mutation and vitamin D status on induction of renal 25-hydroxyvitamin D3-24-hydroxylase (1987), Endocrinology, 120, 609-616.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1alpha,25-dihydroxyvitamin D3 renal 24-hydroxylase is significantly stimulated by 1alpha,25-dihydroxyvitamin D3 treatment in both normal and Hyp mice. In normal mice, 1alpha,25-dihydroxyvitamin D3 treatment is more effective than calcium in turning on 24-hydroxylase activity. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone. 24-hydroxylase is 3fold, and 8fold greater in Hyp mice relative to normal treated with 1alpha,25-dihydroxyvitamin D3, and calcium plus 1alpha,25-dihydroxyvitamin D3, respectively Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ 24-hydroxylase activity is 20fold greater in Hyp mice relative to normal treated with calcium. In Hyp mice, treatment with calcium plus 1alpha,25-dihydroxyvitamin D3 results in a greater increase in 24-hydroxylase than treatment with either agent alone Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
Mus musculus secalciferol + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
24-hydroxylase
-
Mus musculus
25-hydroxyvitamin D-24-hydroxylase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus