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Literature summary for 1.14.15.16 extracted from

  • Masuda, S.; Strugnell, S.A.; Knutson, J.C.; St-Arnaud, R.; Jones, G.
    Evidence for the activation of 1alpha-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: Delineation of pathways involving 1alpha,24-dihydroxyvitamin D2 and 1alpha,25-dihydroxyvitamin D2 (2006), Biochim. Biophys. Acta, 1761, 221-234.
    View publication on PubMed
Search for more literature for 1.14.15.16

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HPK1A-ras cell
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 Homo sapiens
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keratinocyte
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 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha-hydroxyvitamin D2 + NADPH + H+ + O2
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 Mus musculus 1alpha,24-dihydroxyvitamin D2 + 1alpha,25-dihydroxyvitamin D2 + 26-carboxy-1alpha,24-dihydroxyvitamin D2 + NADP+ + H2O
-
 ?
1alpha-hydroxyvitamin D2 + NADPH + H+ + O2
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 Homo sapiens 1alpha,24-dihydroxyvitamin D2 + 1alpha,25-dihydroxyvitamin D2 + 26-carboxy-1alpha,24-dihydroxyvitamin D2 + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
25-hydroxyvitamin D-24-hydroxylase
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 Mus musculus
25-hydroxyvitamin D-24-hydroxylase
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 Homo sapiens
CYP24A1
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 Mus musculus
CYP24A1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function CYP24A1 can activate and inactivate vitamin D prodrugs in skin and other target cells in vitro Mus musculus
physiological function CYP24A1 can activate and inactivate vitamin D prodrugs in skin and other target cells in vitro Homo sapiens