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Literature summary for 1.14.15.16 extracted from

  • Kusudo, T.; Sakaki, T.; Abe, D.; Fujishima, T.; Kittaka, A.; Takayama, H.; Hatakeyama, S.; Ohta, M.; Inouye, K.
    Metabolism of A-ring diastereomers of 1alpha,25-dihydroxyvitamin D3 by CYP24A1 (2004), Biochem. Biophys. Res. Commun., 321, 774-782.
    View publication on PubMed
Search for more literature for 1.14.15.16

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM109 cells Homo sapiens
expressed in Escherichia coli JM109 cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00006
-
 1alpha,25-dihydroxyvitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
0.00006
-
 1beta,25-dihydroxyvitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
0.00015
-
 1alpha,25-dihydroxy-3-epi-vitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
0.00018
-
 25-hydroxyvitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens
0.0012
-
 1beta,25-dihydroxy-3-epi-vitamin D3 in 0.1 mM Tris-HCl (pH 7.4), temperature not specified in the publication Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha,25-dihydroxy-3-epi-vitamin D3 + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
1alpha,25-dihydroxy-3-epivitamin-D3 + NADPH + H+ + O2
-
 Rattus norvegicus ?
-
 ?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Rattus norvegicus 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1beta,25-dihydroxy-3-epi-vitamin D3 + NADPH + H+ + O2
-
 Homo sapiens ?
-
 ?
1beta,25-dihydroxy-3-epivitamin-D3 + NADPH + H+ + O2
-
 Rattus norvegicus ?
-
 ?
1beta,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens ? + NADP+ + H2O
-
 ?
1beta,25-dihydroxyvitamin D3 + NADPH + H+ + O2
-
 Rattus norvegicus ? + NADP+ + H2O
-
 ?
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Homo sapiens 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
25-hydroxyvitamin D3 + NADPH + H+ + O2
-
 Rattus norvegicus 24R,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP24A1
-
 Homo sapiens
CYP24A1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus