Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5beta-cholestane-3alpha,7alpha,12alpha-triol | inhibits 5beta-cholestane-3alpha,7alpha-diol 27-monooxygenase activity | Rattus norvegicus | |
5beta-cholestane-3alpha,7alpha-diol | inhibits 5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase activity only slightly | Rattus norvegicus | |
Ca2+ | complete inhibition at 1 mM | Rattus norvegicus | |
Metyrapone | slight inhibition of 27-monooxygenase | Rattus norvegicus | |
p-chloromercuribenzoate | complete inhibition at 1 mM | Rattus norvegicus | |
Phenyl isocyanide | complete inhibition at 1 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0045 | - |
5beta-cholestane-3alpha,7alpha,12alpha-triol | - |
Rattus norvegicus | |
0.01 | - |
5beta-cholestane-3alpha,7alpha-diol | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Rattus norvegicus | 31966 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 | - |
Rattus norvegicus | 5beta-cholestane-3alpha,7alpha,12alpha,27-tetrol + oxidized adrenodoxin + H2O | - |
? | |
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 | - |
Rattus norvegicus | ? | - |
? | |
5beta-cholestane-3alpha-ol + reduced adrenodoxin + O2 | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5beta-cholestane-3alpha,7alpha,12alpha-triol 27-monooxygenase | enzyme was renamed into 27-monooxygenase because it hydroxylates the methyl group in position 27 | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.7 | - |
- |
Rattus norvegicus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 8 | 27-hydroxylation | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
5beta-cholestane-3alpha,7alpha,12alpha-triol | - |
Rattus norvegicus |