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Literature summary for 1.14.14.29 extracted from

  • Li-Hawkins, J.; Lund, E.G.; Turley, S.D.; Russell, D.W.
    Disruption of the oxysterol 7alpha-hydroxylase gene in mice (2000), J. Biol. Chem., 275, 16536-16542.
    View publication on PubMed
Search for more literature for 1.14.14.29

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 Mus musculus loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 Mus musculus loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
 Mus musculus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways Mus musculus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
 Mus musculus cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?
cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways Mus musculus cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP7B1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus