Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.24 extracted from

  • Aiba, I.; Yamasaki, T.; Shinki, T.; Izumi, S.; Yamamoto, K.; Yamada, S.; Terato, H.; Ide, H.; Ohyama, Y.
    Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases (2006), Steroids, 71, 849-856.
    View publication on PubMed
Search for more literature for 1.14.14.24

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus
expression in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
 vitamin D2 pH 7.7, 37°C Homo sapiens
0.0044
-
 1alpha-hydroxyvitamin D3 pH 7.7, 37°C Homo sapiens
0.0077
-
 vitamin D3 pH 7.7, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P51589
-
-
Rattus norvegicus P51590
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1alpha-hydroxyvitamin D3 + O2 + NADPH + H+
-
 Rattus norvegicus 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
1alpha-hydroxyvitamin D3 + O2 + NADPH + H+
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D3 + NADP+ + H2O
-
 ?
25-hydroxyvitamin D3 + O2 + NADPH + H+
-
 Homo sapiens 1alpha,25-dihydroxyitamin D3 + NADP+ + H2O additional product: 24,25-dihydroxyvitamin D3 ?
ebastin + O2 + NADPH + H+ histamine H1-recepter antagonist Rattus norvegicus ? + NADP+ + H2O
-
 ?
vitamin D2 + O2 + NADPH + H+
-
 Rattus norvegicus 25-hydroxyvitamin D2 + NADP+ + H2O
-
 ?
vitamin D2 + O2 + NADPH + H+
-
 Homo sapiens 25-hydroxyvitamin D2 + NADP+ + H2O
-
 ?
vitamin D3 + O2 + NADPH + H+
-
 Rattus norvegicus 25-hydroxyvitamin D3 + NADP+ + H2O
-
 ?
vitamin D3 + O2 + NADPH + H+
-
 Homo sapiens 25-hydroxyvitamin D3 + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYPIIJ3
-
 Rattus norvegicus
cytochrome P450 2J2
-
 Homo sapiens
Cytochrome P450 2J3
-
 Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0015
-
 vitamin D3 pH 7.7, 37°C Homo sapiens
0.0027
-
 vitamin D2 pH 7.7, 37°C Homo sapiens
0.014
-
 vitamin D2 pH 7.7, 37°C Rattus norvegicus
0.017
-
 vitamin D3 pH 7.7, 37°C Rattus norvegicus
0.037
-
 1alpha-hydroxyvitamin D3 pH 7.7, 37°C Homo sapiens
0.367
-
 1alpha-hydroxyvitamin D3 pH 7.7, 37°C Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus
NADPH
-
 Homo sapiens