Cloned (Comment) | Organism |
---|---|
mutant Cyp7A1 promoter fragment cloned luciferase construct is generated using wild-type CYP7A1 promoter cloned luciferase, the gene contains a HSF-1 binding site in the CYP7A1 promoter region, oligonucleotides corresponding to -922 to -901 bases | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a mutant CYP7A1 promoter luciferase construct with deletion of putative HSE binding site for HSF-1, in the CYP7A1 promoter region (-922 to -901) and determination of luciferase activity in the hepatocytes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q64505 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha hydroxylase | - |
Mus musculus |
CYP7A1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis | up |
General Information | Comment | Organism |
---|---|---|
malfunction | heat shock factor-1 ablation not only eliminates heat shock response, but it also transcriptionally upregulates CYP7A1 and MDR1/P-gp axis in atherogenic western diet-diet fed HSF-1 and low density lipoproteins receptor double knock out mice to reduce atherosclerosis | Mus musculus |
metabolism | HSF-1 deletion reduces atherosclerosis and enhances dietary cholesterol metabolism, by not only inducing hepatic MDR1/Pgp but also by enhancing CYP7A1 gene expression in the liver. HSF-1 is a metabolic regulator of dietary cholesterol | Mus musculus |
physiological function | heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis | Mus musculus |