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Literature summary for 1.14.14.23 extracted from

  • Krishnamurthy, K.; Glaser, S.; Alpini, G.; Cardounel, A.J.; Liu, Z.; Ilangovan, G.
    Heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis (2016), Cardiovasc. Res., 111, 74-83.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
mutant Cyp7A1 promoter fragment cloned luciferase construct is generated using wild-type CYP7A1 promoter cloned luciferase, the gene contains a HSF-1 binding site in the CYP7A1 promoter region, oligonucleotides corresponding to -922 to -901 bases Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of a mutant CYP7A1 promoter luciferase construct with deletion of putative HSE binding site for HSF-1, in the CYP7A1 promoter region (-922 to -901) and determination of luciferase activity in the hepatocytes Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q64505
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-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
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liver
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Mus musculus
-

Synonyms

Synonyms Comment Organism
cholesterol 7alpha hydroxylase
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Mus musculus
CYP7A1
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Mus musculus

Expression

Organism Comment Expression
Mus musculus heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis up

General Information

General Information Comment Organism
malfunction heat shock factor-1 ablation not only eliminates heat shock response, but it also transcriptionally upregulates CYP7A1 and MDR1/P-gp axis in atherogenic western diet-diet fed HSF-1 and low density lipoproteins receptor double knock out mice to reduce atherosclerosis Mus musculus
metabolism HSF-1 deletion reduces atherosclerosis and enhances dietary cholesterol metabolism, by not only inducing hepatic MDR1/Pgp but also by enhancing CYP7A1 gene expression in the liver. HSF-1 is a metabolic regulator of dietary cholesterol Mus musculus
physiological function heat shock factor-1 knockout enhances cholesterol 7alpha hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis Mus musculus