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Literature summary for 1.14.14.23 extracted from

  • Li, T.; Chanda, D.; Zhang, Y.; -SikChoi, H.; Chiang, J.
    Glucose stimulates cholesterol 7 alpha-hydroxylase gene transcription in human hepatocytes (2010), J. Lipid Res., 51, 832-842.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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gene CYP7A1
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
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Homo sapiens
-
liver
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Homo sapiens
-

Synonyms

Synonyms Comment Organism
cholesterol 7 alpha-hydroxylase
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Homo sapiens
CYP7A1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens activation of an AMP-activated protein kinase decreases CYP7A1 mRNA, hepatocyte nuclear factor 4alpha protein, and binding to CYP7A1 chromatin down
Homo sapiens high glucose stimulates bile acid synthesis and induces mRNA expression of cholesterol 7alpha-hydroxylase, the key regulatory gene in bile acid synthesis. Glucose increased ATP levels to inhibit AMPK and induce HNF4alpha to stimulate CYP7A1 gene transcription. Knockdown of ATP-citrate lyase, which converts citrate to acetyl-CoA, decreases histone acetylation, and attenuates glucose induction of CYP7A1 mRNA expression up

General Information

General Information Comment Organism
metabolism the phosphorylation status of CYP7A1 chromatin is important in CYP7A1 regulation, overview Homo sapiens
additional information high glucose stimulates bile acid synthesis and induces mRNA expression of cholesterol 7 alpha-hydroxylase, the key regulatory gene in bile acid synthesis. Glucose decreases H3K9 methylation in CYP7A1 chromatin. Knockdown of ATP-citrate lyase, which converts citrate to acetyl-CoA, decreases histone acetylation, and attenuates glucose induction of CYP7A1 mRNA expression Homo sapiens