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Literature summary for 1.14.14.23 extracted from

  • Li, T.; Owsley, E.; Matozel, M.; Hsu, P.; Novak, C.M.; Chiang, J.Y.
    Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice (2010), Hepatology, 52, 678-690.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information construction of Cyp7a1-tg mice overexpressing rat Cyp7a1, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gall bladder
-
 Mus musculus
-
intestine
-
 Mus musculus
-
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
 Mus musculus
CYP7A1
-
 Mus musculus

General Information

General Information Comment Organism
additional information transgenic mice overexpressing Cyp7a1 in the liver are resistant to high-fat diet-induced obesity, fatty liver, and insulin resistance. Cyp7a1-tg mice show increased hepatic cholesterol catabolism and an increased bile acid pool, they have increased secretion of hepatic very low density lipoprotein but maintained plasma triglyceride homeostasis, phenotype, overview Mus musculus
physiological function cholesterol 7alpha-hydroxylase is the rate-limiting enzyme in the bile acid biosynthetic pathway that converts cholesterol into bile acids in the liver. Bile acids play an important role in maintaining lipid, glucose, and energy homeostasis Mus musculus