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Literature summary for 1.14.14.23 extracted from

  • Srivastava, A.; Pandey, S.N.; Choudhuri, G.; Mittal, B.
    Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer (2008), Mol. Genet. Metab., 94, 83-89.
    View publication on PubMed

Application

Application Comment Organism
medicine association of CYP7A1 gene polymorphisms with the risk of gallbladder cancer. This polymorphism plays a significant role in the pathogenesis of gallbladder cancer which is causatively related to depressed bile acid production. The proposed tumorigenic mechanism for gallbladder cancer is independent of gallstone pathway and appears to be mediated by increase in concentration and accumulation of toxic substances in gallbladder, generated in liver as a consequence of lipid peroxidation and other catabolic reactions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
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Homo sapiens
CYP7A1
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Homo sapiens