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Literature summary for 1.14.14.23 extracted from

  • Li, T.; Kong, X.; Owsley, E.; Ellis, E.; Strom, S.; Chiang, J.Y.
    Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c (2006), J. Biol. Chem., 281, 28745-28754.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.23

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP7A1, transient expression in Hep-G2 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information mechanism of insulin regulation of CYP7A1 gene expression in human hepatocytes, physiological concentrations of insulin rapidly stimulate CYP7A1 mRNA expression in primary human hepatocytes but inhibit CYP7A1 expression after extended treatment, forkhead box O1 and sterol regulatory element-binding protein 1c are involved, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens insulin, forkhead box O1, and sterol regulatory element-binding protein 1c are involved in regulation of expression of gene CYP7A1, genetic mechanism, overview 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P22680 gene CYP7A1
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte primary, CYP7A1 expression analysis in absence or presence of isnulin Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 insulin, forkhead box O1, and sterol regulatory element-binding protein 1c are involved in regulation of expression of gene CYP7A1, genetic mechanism, overview Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 7alpha-hydroxylase
-
 Homo sapiens
CYP7A1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens