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Literature summary for 1.14.14.19 extracted from

  • Jin, G.X.; Wen, H.S.; He, F.; Li, J.F.; Chen, C.F.; Zhang, J.R.; Chen, X.Y.; Shi, B.; Shi, D.; Yang, Y.P.; Qi, B.X.; Li, N.
    Molecular cloning, characterization expression of P450c17-I and P450c17-II and their functions analysis during the reproductive cycle in males of barfin flounder (Verasper moseri) (2012), Fish Physiol. Biochem., 38, 807-817.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene P450c17-I, DNA and amino acid sequence determination and analysis, phylogenetic analysis, semiquantitative RT-PCR enzyme expression analysis Verasper moseri
gene P450c17-II, DNA and amino acid sequence determination and analysis, phylogenetic analysis, semiquantitative RT-PCR enzyme expression analysis Verasper moseri

Organism

Organism UniProt Comment Textmining
Verasper moseri B3VLB1 P450c17-I; male fish from an aquatic farm in Yantai City, Shandong, China, gene P450c17-I
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Verasper moseri B6UPD2 P450c17-II; male fish from an aquatic farm in Yantai City, Shandong, China, gene P450c17-II
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Verasper moseri
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head kidney high level of P450c17-II expression Verasper moseri
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kidney
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Verasper moseri
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additional information semiquantitative RT-PCR enzyme tissue expression analysis, P450c17-I mRNA expression during the testicular cycle, overview Verasper moseri
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additional information semiquantitative RT-PCR enzyme tissue expression analysis, P450c17-II mRNA expression during the testicular cycle, overview Verasper moseri
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ovary
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Verasper moseri
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testis
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Verasper moseri
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testis high level of P450c17-I Verasper moseri
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Synonyms

Synonyms Comment Organism
P450c17
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Verasper moseri

General Information

General Information Comment Organism
physiological function P450c17, a key steroidogenic enzyme, plays important roles in the production of sex steroid and cortisol. In teleost, there are two types of P450c17, P450c17-I possessing 17alpha-hydroxylase and 17,20-lyase activities, and P450c17-II only possessing 17alpha-hydroxylase activity. Only P450c17-II is involved in the production of cortisol in barfin flounder Verasper moseri
physiological function P450c17, a key steroidogenic enzyme, plays important roles in the production of sex steroid and cortisol. In teleost, there are two types of P450c17, P450c17-I possessing 17alpha-hydroxylase and 17,20-lyase activities, and P450c17-II only possessing 17alpha-hydroxylase activity. P450c17-I is not involved in the production of cortisol in barfin flounder Verasper moseri