Literature summary for 1.14.14.19 extracted from

Kaku, T.; Matsunaga, N.; Ojida, A.; Tanaka, T.; Hara, T.; Yamaoka, M.; Kusaka, M.; Tasaka, A.
17,20-lyase inhibitors. Part 4: design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors (2011), Bioorg. Med. Chem., 19, 1751-1770.

Search for more literature for 1.14.14.19

Inhibitors

Inhibitors	Comment	Organism
(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Homo sapiens
(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Rattus norvegicus
(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Homo sapiens
(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Rattus norvegicus
(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Homo sapiens
(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Rattus norvegicus
(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Homo sapiens
(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Rattus norvegicus
(1S)-1-(1H-imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methylpropan-1-ol	-	Rattus norvegicus
1-chloro-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide	-	Homo sapiens
1-chloro-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide	-	Rattus norvegicus
1-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-1-ethanone	-	Homo sapiens
1-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-1-ethanone	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-2,3-dihydro-1H-benzo[f]isoindol-1-one	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-2,3-dihydro-1H-benzo[f]isoindol-1-one	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,1-dimethyl-2-naphthamide	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,1-dimethyl-2-naphthamide	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,3-dimethyl-2-naphthamide	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,3-dimethyl-2-naphthamide	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-isopropyl-2-naphthamide	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-isopropyl-2-naphthamide	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide	-	Rattus norvegicus
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-propyl-2-naphthamide	-	Homo sapiens
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-propyl-2-naphthamide	-	Rattus norvegicus
7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Homo sapiens
7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Rattus norvegicus
7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Homo sapiens
7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one	-	Rattus norvegicus
abiraterone acetate	-	Homo sapiens
abiraterone acetate	-	Rattus norvegicus
methyl 6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthoate	-	Homo sapiens
methyl 6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthoate	-	Rattus norvegicus
N'-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-N-methylurea	-	Homo sapiens
N'-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-N-methylurea	-	Rattus norvegicus
N-ethyl-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide	-	Homo sapiens
N-ethyl-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide	-	Rattus norvegicus
N-[4'-[(1S)-1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]biphenyl-3-yl]acetamide	-	Rattus norvegicus
N-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]acetamide	-	Homo sapiens
N-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]acetamide	-	Rattus norvegicus
YM-116	-	Homo sapiens
YM-116	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
17alpha-hydroxyprogesterone + AH2 + O2	-	Homo sapiens	?	-	?
17alpha-hydroxyprogesterone + AH2 + O2	-	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
17,20-lyase	-	Homo sapiens
17,20-lyase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
cytochrome b5	-	Homo sapiens
cytochrome b5	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000006	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide
0.00001	-	IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide
0.00001	-	IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.00001	-	IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.00001	-	IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.000011	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	N'-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-N-methylurea
0.000011	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	N-ethyl-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide
0.000012	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-isopropyl-2-naphthamide
0.000012	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,3-dimethyl-2-naphthamide
0.000013	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-propyl-2-naphthamide
0.000014	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	1-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-1-ethanone
0.000015	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.000015	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.000016	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide
0.000018	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.000019	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-2,3-dihydro-1H-benzo[f]isoindol-1-one
0.000019	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.000021	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	(1S)-1-(1H-imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methylpropan-1-ol
0.000022	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.000024	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	methyl 6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthoate
0.000028	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	1-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-1-ethanone
0.000028	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	(1S)-1-(1H-imidazol-4-yl)-1-(6-methoxynaphthalen-2-yl)-2-methylpropan-1-ol
0.000029	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	N-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]acetamide
0.00003	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide
0.000036	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	N'-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]-N-methylurea
0.000036	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one
0.000038	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-propyl-2-naphthamide
0.000039	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	N-[6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthyl]acetamide
0.000039	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,3-dimethyl-2-naphthamide
0.000042	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2,3-dihydro-1H-benzo[f]isoindol-1-one
0.000043	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	methyl 6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthoate
0.000046	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	N-ethyl-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide
0.00006	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.00007	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-2,3-dihydro-1H-benzo[f]isoindol-1-one
0.000075	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-isopropyl-2-naphthamide
0.000091	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	1-chloro-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide
0.00011	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.00016	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,1-dimethyl-2-naphthamide
0.00018	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one
0.0002	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	1-chloro-6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide
0.0002	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Rattus norvegicus	6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N,1-dimethyl-2-naphthamide
0.00027	-	in 75 mM phosphate buffer (pH 7.4), at 37°C	Homo sapiens	(+)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one