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Literature summary for 1.14.14.19 extracted from

  • Li, Y.; Liang, X.; Wei, L.; Xiong, Y.; Yang, X.; Shi, H.; Yang, Z.
    Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo (2009), Reprod. Biol. Endocrinol., 7, 73-80.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP17, expression analysis Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in androstenedione production ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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female Sprague-Dawley rats, gene CYP17
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
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ovarian theca-interstitial cell
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Rattus norvegicus
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ovary
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in androstenedione production Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase/17,20-lyase
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus three CYP17-targeting lentivirus shRNAs, targeting different sites of CYP17, are constructed and synthesized, that all have a silencing effect on CYP17 mRNA and protein, which leads to a decline of all the levels of androstenedione, 17-hydroxyprogesterone and testosterone to a certain degree, but progesterone levels decline significantly down

General Information

General Information Comment Organism
metabolism CYP17 is the key enzyme in androgen biosynthesis pathway Rattus norvegicus