Cloned (Comment) | Organism |
---|---|
gene CYP17, expression analysis | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in androstenedione production | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
female Sprague-Dawley rats, gene CYP17 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Rattus norvegicus | - |
ovarian theca-interstitial cell | - |
Rattus norvegicus | - |
ovary | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in androstenedione production | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase/17,20-lyase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | three CYP17-targeting lentivirus shRNAs, targeting different sites of CYP17, are constructed and synthesized, that all have a silencing effect on CYP17 mRNA and protein, which leads to a decline of all the levels of androstenedione, 17-hydroxyprogesterone and testosterone to a certain degree, but progesterone levels decline significantly | down |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP17 is the key enzyme in androgen biosynthesis pathway | Rattus norvegicus |