Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition with anti-P-450 reductase or limitation of NADPH preferentially reduce the lyase activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin | ? | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Purification (Comment) | Organism |
---|---|
native enzyme partially from pancreatic cell microsomes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Langerhans cell | - |
Rattus norvegicus | - |
additional information | immunohistochemic enzyme localization analysis, overview | Rattus norvegicus | - |
pancreas | islets of Langerhans | Rattus norvegicus | - |
pancreatic beta cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | CYP17 existence coincide with that of insulin and demarcated those of glucagon and somatostatin | Rattus norvegicus | ? | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P-45017alpha | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
metabolism | Cyp17 is important in the metabolism of androgens, overview | Rattus norvegicus |