Cloned (Comment) | Organism |
---|---|
gene CYP17, coexpression in Escherichia coli with human NADPH-P450 reductase | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-fluoro-4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)phenol hydrobromide | - |
Homo sapiens | |
2-fluoro-4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)phenol hydrobromide | - |
Homo sapiens | |
3-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
3-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(5-(4-methoxyphenyl)-3H-inden-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)benzene-1,2-diol hydrobromide | - |
Homo sapiens | |
4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)benzene-1,2-diol hydrobromide | - |
Homo sapiens | |
4-(6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
4-(6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride | - |
Homo sapiens | |
5-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol | - |
Homo sapiens | |
5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol | - |
Homo sapiens | |
5-(4-fluorophenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol | - |
Homo sapiens | |
5-(4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol | - |
Homo sapiens | |
6-(3,4-difluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol | - |
Homo sapiens | |
6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol | - |
Homo sapiens | |
6-(4-fluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol | - |
Homo sapiens | |
abiraterone | - |
Homo sapiens | |
ketoconazole | - |
Homo sapiens | |
additional information | inhibition design, synthesis, and molecular modelling, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CYP17 | - |
Homo sapiens |
cytochrome P450 17alpha-hydroxylase-17,20-lyase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000064 | - |
- |
Homo sapiens | 2-fluoro-4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)phenol hydrobromide | |
0.000072 | - |
- |
Homo sapiens | abiraterone | |
0.000144 | - |
- |
Homo sapiens | 4-(5-(pyridin-4-yl)-5,6,7,8-tetrahydronaphthalen-2-yl)benzene-1,2-diol hydrobromide | |
0.000163 | - |
- |
Homo sapiens | 4-(6-(4-fluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride | |
0.000188 | - |
- |
Homo sapiens | 2-fluoro-4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)phenol hydrobromide | |
0.000233 | - |
- |
Homo sapiens | 4-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride | |
0.000307 | - |
- |
Homo sapiens | 4-(5-(pyridin-4-yl)-7,8-dihydronaphthalen-2-yl)benzene-1,2-diol hydrobromide | |
0.000333 | - |
- |
Homo sapiens | 5-(4-fluorophenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol | |
0.000423 | - |
- |
Homo sapiens | 6-(3,4-difluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol | |
0.000587 | - |
- |
Homo sapiens | 6-(4-fluorophenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol | |
0.00122 | - |
- |
Homo sapiens | 4-(6-(3,4-difluorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl)pyridine hydrochloride | |
0.00235 | - |
- |
Homo sapiens | 3-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride | |
0.00378 | - |
- |
Homo sapiens | ketoconazole | |
0.005 | - |
above | Homo sapiens | 6-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-ol | |
0.005 | - |
above | Homo sapiens | 4-(5-(4-methoxyphenyl)-3H-inden-1-yl)pyridine hydrochloride | |
0.005 | - |
above | Homo sapiens | 4-(6-(3,4-difluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride | |
0.005 | - |
above | Homo sapiens | 4-(6-(4-fluorophenyl)-3,4-dihydronaphthalen-1-yl)pyridine hydrochloride | |
0.01 | - |
above | Homo sapiens | 5-(3-fluoro-4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol | |
0.02 | - |
above | Homo sapiens | 5-(4-fluorophenyl)-1-(pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol | |
0.02 | - |
above | Homo sapiens | 5-(4-methoxyphenyl)-1-(pyridin-4-yl)-2,3-dihydro-1H-inden-1-ol | |
0.02 | - |
above | Homo sapiens | 4-(5-(4-fluorophenyl)-3H-inden-1-yl)pyridine hydrochloride | |
0.02 | - |
above | Homo sapiens | 3-(5-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl)pyridine hydrochloride |