Inhibitors | Comment | Organism | Structure |
---|---|---|---|
22-Amino-23,24-bisnor-5-cholen-3beta-ol | type II competitive inhibitor | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | endoplasmic reticulum | Bos taurus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe3+ | heme | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | Bos taurus | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Bos taurus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | - |
Bos taurus | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Bos taurus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000029 | - |
22-Amino-23,24-bisnor-5-cholen-3beta-ol | 17alpha-hydroxylase activity | Bos taurus |