Any feedback?
Literature summary for 1.14.14.19 extracted from
- Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17alpha-hydroxylase: 17,20-lyase (P450 17) and their specificity patterns (1998), J. Pharm. Pharmacol., 50, 1109-1116.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[(5,7-dibromobenzofuran-2-yl)methyl]imidazole | at 1150 nM 50% inhibition | Bos taurus |  |
| 1-[(5,7-dibromobenzofuran-2-yl)methyl]imidazole | at 185 nM 50% inhibition | Homo sapiens | |
| 1-[(5,7-dichlorobenzofuran-2-yl)methyl]imidazole | at 1300 nM 50% inhibition | Bos taurus | |
| 1-[(5,7-dichlorobenzofuran-2-yl)methyl]imidazole | at 180 nM 50% inhibition | Homo sapiens | |
| 1-[(5-bromobenzofuran-2-yl)methyl]imidazole | at 1540 nM 50% inhibition | Bos taurus | |
| 1-[(5-bromobenzofuran-2-yl)methyl]imidazole | at 380 nM 50% inhibition | Homo sapiens | |
| 1-[(5-chlorobenzofuran-2-yl)methyl]imidazole | at 1800 nM 50% inhibition | Bos taurus | |
| 1-[(5-chlorobenzofuran-2-yl)methyl]imidazole | at 230 nM 50% inhibition | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pregnenolone + AH2 + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| pregnenolone + AH2 + O2 | Bos taurus | - |
17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Bos taurus | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Bos taurus | - |
| testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pregnenolone + AH2 + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| pregnenolone + AH2 + O2 | - |
Bos taurus | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
| progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Bos taurus | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | product eliminates at C20,21 acetate to yield androstenedione | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| P450 17 | - |
Homo sapiens |
| P450 17 | - |
Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
| 7.4 | - |
assay at | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Bos taurus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
