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Literature summary for 1.14.14.19 extracted from

  • Recanatini, M.; Bisi, A.; Cavalli, A.; Belluti, F.; Gobbi, S.; Rampa, A.; Valenti, P.; Palzer, M.; Palusczak, A.; Hartmann, R.W.
    A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17alpha-hydroxylase/C17,20-lyase (2001), J. Med. Chem., 44, 672-680.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1-(imidazol-1-ylmethyl)-4-bromo-9H-9-xanthenone at 0.0025 mM 98% inhibition Homo sapiens
1-(imidazol-1-ylmethyl)-4-nitro-9H-9-xanthenone at 0.0025 mM 94% inhibition Homo sapiens
1-(imidazol-1-ylmethyl)-9-oxo-9H-4-xanthenecarbonitrile at 0.0025 mM 92% inhibition Homo sapiens
ketoconazole at 0.00074 mM 50% inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O product eliminates at C20,21 acetate to yield androstenedione ?

Synonyms

Synonyms Comment Organism
P450 17
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens