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Literature summary for 1.14.14.18 extracted from

  • Fei, D.; Meng, X.; Kang, K.; Nan, C.; Zhao, M.; Pan, S.; Gao, M.; Yang, S.; Zhao, M.
    Heme oxygenase-1 modulates thrombomodulin and activated protein C levels to attenuate lung injury in cecal ligation and puncture-induced acute lung injury mice (2012), Exp. Lung Res., 38, 173-182.
    View publication on PubMed
Search for more literature for 1.14.14.18

Inhibitors

Inhibitors Comment Organism Structure
zinc protoporphyrin
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoheme + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus
-
 biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoheme + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus biliverdin + Fe2+ + CO + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Mus musculus
HO-1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus pretreatment with hemin causes up-regulation of enzyme expression up

General Information

General Information Comment Organism
physiological function the enzyme exhibits protective effects on cecal ligation and puncture-induced acute lung injury via regulating cell surface thrombomodulin and activated protein C expression and modulating blood coagulation Mus musculus