Inhibitors | Comment | Organism | Structure |
---|---|---|---|
zinc protoporphyrin | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | - |
Mus musculus | |
Fe2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + electron donor + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + oxidized electron donor + H2O | - |
? | |
heme + electron donor + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + oxidized electron donor + H2O | - |
? | |
heme + electron donor + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized electron donor + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Mus musculus |
heme oxygenase-1 | - |
Homo sapiens |
heme oxygenase-1 | - |
Rattus norvegicus |
HO-1 | - |
Mus musculus |
HO-1 | - |
Homo sapiens |
HO-1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus | |
heme | - |
Homo sapiens | |
heme | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | pretreatment with hemoglobin induces HO-1 and significantly reduces systemic inflammations associated with plasma concentrations of TNFalpha levels due to intestinal ischemia/reperfusion injury | up |
General Information | Comment | Organism |
---|---|---|
physiological function | human patient wiht HO-1-deficiency died in his childhood with clinical manifestations, including growth failure, anemia, tissue iron deposition, lymphoadenopathy, leukocytosis and increased sensitivity to oxidative injury. HO-1 serves to provide cytoprotection against oxidative stress and is necessary in mammals | Homo sapiens |
physiological function | inducible form of HO-1, biliverdin, and CO possess generalized endogenous anti-inflammatory activities and provide protection against intestinal ischemia/reperfusion injury. Exogenous HO-1 expression, as well as exogenously administered CO and biliverdin, have potent cytoprotective effects on intestinal ischemia/reperfusion injury as well | Rattus norvegicus |
physiological function | mice lacking the HO-1 gene frequently die in utero, and the mice that survive to adulthood exhibit growth failure, anemia, chronic inflammation characterized by hepatosplenomegaly, leukocytosis, glomerulonephritis, and histological hepatoportal cellular infiltration. HO-1 serves to provide cytoprotection against oxidative stress and is necessary in mammals | Mus musculus |