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Literature summary for 1.14.14.18 extracted from

  • Bilban, M.; Haslinger, P.; Prast, J.; Klinglmueller, F.; Woelfel, T.; Haider, S.; Sachs, A.; Otterbein, L.E.; Desoye, G.; Hiden, U.; Wagner, O.; Knoefler, M.
    Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma (2009), Endocrinology, 150, 1000-1013.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
293FT cells transiently cotransfected with a vector containing the viral packaging proteins gag and pol, a vector containing env and pMSCV-scrttaM2puro or pRevTRE-hHO1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BeWo cell high HO-1 expression Homo sapiens
-
cytotrophoblast in vivo, high HO-1 expression. HO-1 protein is strongly expressed in proliferative, Ki67-positive cytotrophoblasts of cell columns. HO-1 is strongly expressed in cycling cytotrophoblasts of first trimester explant cultures Homo sapiens
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HTR-8/SVneo cell
-
 Homo sapiens
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HTR-8/SVneo cell low HO-1 expression Homo sapiens
-
additional information in vivo, no HO-1 expression in extravillous trophoblasts and in nonproliferating, Kip2/p57-positive extravillous trophoblasts Homo sapiens
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trophoblast
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Homo sapiens
HO-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HO-1 expression is reduced upon differentiation of cytotrophoblasts into extravillous trophoblasts. Knock down of endogenous HO-1 in BeWo cells using retroviral transduction with a miRNA adapted retroviral vector targeting human HO-1 sequence down
Homo sapiens HO-1 protein expression is strongly induced 24 h after DOX addition in the HTR-8/SVneo cell line up

General Information

General Information Comment Organism
physiological function HO-1 is a negative regulator of trophoblast motility acting via up-regulation of peroxisome proliferator activated receptor (PPAR) gamma. In wound healing assays, trophoblast migration into the denuded area is diminished upon induction of HO-1 Homo sapiens