Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | a higher dilauroylphosphatidylcholine/HO-1 ratio than typically used provides an improved environment for HO-1 activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R254K | enhances protein stability during the glutathione S-transferase-tag removal procedure involving the protease thrombin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | HO-1-generated hydrogen peroxide leads to a decrease in HO-1 activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | presence of the membrane-spanning region on HO-1 is required for efficient membrane incorporation, which is achieved after a 2 h preincubation period at room temperature | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-80°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + electron donor + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + oxidized electron donor + H2O | - |
? | |
additional information | ability of uncoupled HO-1 to produce large quantities of H2O2, H2O2 generation is much more efficient with the full-length form of HO-1 than with the soluble form | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | because HO-1 and NADPH-cytochrome P450 reductase (CPR) are membrane-bound proteins, the presence of membrane hydrophobic milieu (dilauroylphosphatidylcholine or endoplasmic reticulum membrane) may alter the mechanism by which cytosolic biliverdin reductase metabolizes its substrate biliverdin to bilirubin | Homo sapiens |