Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cobalt protoporphyrin | i.e. CoPP, significantly reduces the viability of glioma cells GBM8401 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine does not protect against cell death | Homo sapiens | |
cobalt protoporphyrin | i.e. CoPP, significantly reduces the viability of glioma cells C6 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine does not protect against cell death | Rattus norvegicus | |
ferric protoporphyrin | i.e. FePP or hemin, significantly reduces the viability of glioma cells GBM8401 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine protects against cell death | Homo sapiens | |
ferric protoporphyrin | i.e. FePP or hemin, significantly reduces the viability of glioma cells C6 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine protects against cell death | Rattus norvegicus | |
tin protoporphyrin | i.e. SnPP, does not affect the viability of glioma cells GBM8401 in the absence of serum | Homo sapiens | |
tin protoporphyrin | i.e. SnPP, does not affect the viability of glioma cells C6 in the absence of serum | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | - |
biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Rattus norvegicus | - |
biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Rattus norvegicus | P06762 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C6 glioma cell | - |
Rattus norvegicus | - |
GBM 8401 cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
glioma cell | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
heme oxygenase-1 | - |
Rattus norvegicus |
HO-1 | - |
Homo sapiens |
HO-1 | - |
Rattus norvegicus |