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Literature summary for 1.14.14.18 extracted from

  • Chow, J.M.; Huang, G.C.; Lin, H.Y.; Shen, S.C.; Yang, L.Y.; Chen, Y.C.
    Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1 (2008), Toxicol. Lett., 177, 97-107.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cobalt protoporphyrin i.e. CoPP, significantly reduces the viability of glioma cells GBM8401 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine does not protect against cell death Homo sapiens
cobalt protoporphyrin i.e. CoPP, significantly reduces the viability of glioma cells C6 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine does not protect against cell death Rattus norvegicus
ferric protoporphyrin i.e. FePP or hemin, significantly reduces the viability of glioma cells GBM8401 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine protects against cell death Homo sapiens
ferric protoporphyrin i.e. FePP or hemin, significantly reduces the viability of glioma cells C6 in the absence of serum, fetal bovine serum or bovine serum albumin completely abolishes the cytotoxic effect, overview, N-acetyl-l-cysteine protects against cell death Rattus norvegicus
tin protoporphyrin i.e. SnPP, does not affect the viability of glioma cells GBM8401 in the absence of serum Homo sapiens
tin protoporphyrin i.e. SnPP, does not affect the viability of glioma cells C6 in the absence of serum Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens
-
biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Rattus norvegicus
-
biliverdin + Fe2+ + CO + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-
Rattus norvegicus P06762
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C6 glioma cell
-
Rattus norvegicus
-
GBM 8401 cell
-
Homo sapiens
-
glioblastoma cell
-
Homo sapiens
-
glioma cell
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2
-
Rattus norvegicus biliverdin + Fe2+ + CO + A + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Homo sapiens
heme oxygenase-1
-
Rattus norvegicus
HO-1
-
Homo sapiens
HO-1
-
Rattus norvegicus