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Literature summary for 1.14.14.18 extracted from

  • Reichard, J.F.; Motz, G.T.; Puga, A.
    Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1 (2007), Nucleic Acids Res., 35, 7074-7086.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information oxidative stress and arsenite strongly induce HMOX1, heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1, BACH1 repression is dominant over NRF2-mediated HMOX1 transcription and inactivation of BACH1 is a prerequisite for HMOX1 induction, but nuclear accumulation of NRF2 is not necessary for HMOX1 induction Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens HO-1 gene regulation system, dynamic roles of transcriptional repressor BACH1 and transcription factor NRF2 in the transcription of the heme oxygenase-1 gene, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens P09601 gene HMOX1
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Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
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Homo sapiens
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keratinocyte
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information HO-1 gene regulation system, dynamic roles of transcriptional repressor BACH1 and transcription factor NRF2 in the transcription of the heme oxygenase-1 gene, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
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Homo sapiens
HO-1
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Homo sapiens