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Literature summary for 1.14.14.18 extracted from
- The role of PDE5 inhibitors in heme oxygenase-cGMP relationship in rat cavernous tissues (2008), J. Sex Med., 5, 1636-1645.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme activity is positively correlated with nitric oxide and cGMP levels in cavernous tissue, overview | Rattus norvegicus | |
| sildenafil | - |
Rattus norvegicus |  |
| tadalafil | - |
Rattus norvegicus | |
| vardenafil | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Zn protoporphyrin | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | Rattus norvegicus | heme degradation | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| additional information | Rattus norvegicus | the enzyme activity is positively correlated with nitric oxide and cGMP levels in cavernous tissue, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cavernous artery | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000015 | - |
cavernous tissue of sildenafil-treated rats | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| heme + AH2 + O2 | heme degradation | Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| additional information | the enzyme activity is positively correlated with nitric oxide and cGMP levels in cavernous tissue, overview | Rattus norvegicus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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