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Literature summary for 1.14.14.18 extracted from

  • Egea, J.; Rosa, A.O.; Cuadrado, A.; Garcia, A.G.; Lopez, M.G.
    Nicotinic receptor activation by epibatidine induces heme oxygenase-1 and protects chromaffin cells against oxidative stress (2007), J. Neurochem., 102, 1842-1852.
    View publication on PubMed
Search for more literature for 1.14.14.18

Activating Compound

Activating Compound Comment Organism Structure
Co-protoporphyrin
-
 Bos taurus
additional information HO-1 is induced by epibatidine via neuronal nicotinic acetylcholine receptors and ERK1/2 in the neuroprotective signaling cascade, overview Bos taurus

Protein Variants

Protein Variants Comment Organism
additional information de novo synthesis of the heme proteins on a membrane-coupled template, and screening for heme proteins with heme oxygenase activity, overview Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Sn(IV) protoporphyrin IX dichloride SnPP Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Bos taurus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Bos taurus HO-1 is a critical cell defence enzyme against oxidative stress, HO-1 participates in the protective effect afforded by neuronal nicotinic acetylcholine receptors, nAChR, activation, which activates the neuroprotective signaling cascade, overview biliverdin + Fe2+ + CO + A + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus Q5E9F2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla chromaffin cells Bos taurus
-
chromaffin cell adrenal medulla Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
 Bos taurus biliverdin + Fe2+ + CO + A + H2O
-
 ?
heme + AH2 + O2 HO-1 is a critical cell defence enzyme against oxidative stress, HO-1 participates in the protective effect afforded by neuronal nicotinic acetylcholine receptors, nAChR, activation, which activates the neuroprotective signaling cascade, overview Bos taurus biliverdin + Fe2+ + CO + A + H2O
-
 ?
additional information screening for heme proteins with heme oxygenase activity after de novo synthesis of the heme proteins on a membrane-coupled template, overview Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
 Bos taurus
HO-1
-
 Bos taurus