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Literature summary for 1.14.14.18 extracted from

  • Hagiya, Y.; Adachi, T.; Ogura, S.; An, R.; Tamura, A.; Nakagawa, H.; Okura, I.; Mochizuki, T.; Ishikawa, T.
    Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy (2008), J. Exp. Ther. Oncol., 7, 153-167.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information induction of HO-1 by hemin and Zn2+-protoporphyrin IX in presence or absence of light, Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens activation of the enzyme leads to induction of the ABC transporter ABCG2, but not of ABCB6 biliverdin + Fe2+ + CO + A + H2O
-
?
additional information Homo sapiens the enzyme is involved in cancer cell response to photodynamic therapy, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 activation of the enzyme leads to induction of the ABC transporter ABCG2, but not of ABCB6 Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
additional information the enzyme is involved in cancer cell response to photodynamic therapy, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Homo sapiens
HO-1
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Homo sapiens