Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | induction of HO-1 by hemin and Zn2+-protoporphyrin IX in presence or absence of light, Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | activation of the enzyme leads to induction of the ABC transporter ABCG2, but not of ABCB6 | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | Homo sapiens | the enzyme is involved in cancer cell response to photodynamic therapy, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | activation of the enzyme leads to induction of the ABC transporter ABCG2, but not of ABCB6 | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | the enzyme is involved in cancer cell response to photodynamic therapy, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |