Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of deletion and/or disruption mutants of HO-1, phenotypes, overview | Homo sapiens |
additional information | construction of deletion and/or disruption mutants of HO-1, phenotypes, overview | Mus musculus |
additional information | construction of deletion and/or disruption mutants of HO-2, phenotypes, overview | Mus musculus |
additional information | construction of deletion and/or disruption mutants of HO-2, phenotypes, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | imidazole-based inhibitor derivatives, overview; imidazole-based inhibitor derivatives, overview | Homo sapiens | |
additional information | imidazole-based inhibitor derivatives, overview; imidazole-based inhibitor derivatives, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Mus musculus | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Mus musculus | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Homo sapiens | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | isozyme HO-1, an inducible heat-shock protein | - |
Homo sapiens | P30519 | constitutive isozyme HO-2 | - |
Mus musculus | O70252 | constitutive isozyme HO-2 | - |
Mus musculus | P14901 | isozyme HO-1, an inducible heat-shock protein | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell | - |
Homo sapiens | - |
germ cell | - |
Mus musculus | - |
leukocyte | - |
Homo sapiens | - |
leukocyte | - |
Mus musculus | - |
liver | high activity | Homo sapiens | - |
liver | high activity | Mus musculus | - |
neuron | - |
Homo sapiens | - |
neuron | - |
Mus musculus | - |
spleen | high activity | Homo sapiens | - |
spleen | high activity | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HO-1 | - |
Homo sapiens |
HO-1 | - |
Mus musculus |
HO-2 | - |
Mus musculus |
HO-2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
- |
Homo sapiens | additional information | |
additional information | - |
- |
Mus musculus | additional information |