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Literature summary for 1.14.14.18 extracted from

  • Kinobe, R.T.; Dercho, R.A.; Nakatsu, K.
    Inhibitors of the heme oxygenase - carbon monoxide system: on the doorstep of the clinic? (2008), Can. J. Physiol. Pharmacol., 86, 577-599.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of deletion and/or disruption mutants of HO-1, phenotypes, overview Homo sapiens
additional information construction of deletion and/or disruption mutants of HO-1, phenotypes, overview Mus musculus
additional information construction of deletion and/or disruption mutants of HO-2, phenotypes, overview Mus musculus
additional information construction of deletion and/or disruption mutants of HO-2, phenotypes, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information imidazole-based inhibitor derivatives, overview; imidazole-based inhibitor derivatives, overview Homo sapiens
additional information imidazole-based inhibitor derivatives, overview; imidazole-based inhibitor derivatives, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Homo sapiens the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Mus musculus the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Mus musculus the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Homo sapiens the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview biliverdin + Fe2+ + CO + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09601 isozyme HO-1, an inducible heat-shock protein
-
Homo sapiens P30519 constitutive isozyme HO-2
-
Mus musculus O70252 constitutive isozyme HO-2
-
Mus musculus P14901 isozyme HO-1, an inducible heat-shock protein
-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell
-
Homo sapiens
-
germ cell
-
Mus musculus
-
leukocyte
-
Homo sapiens
-
leukocyte
-
Mus musculus
-
liver high activity Homo sapiens
-
liver high activity Mus musculus
-
neuron
-
Homo sapiens
-
neuron
-
Mus musculus
-
spleen high activity Homo sapiens
-
spleen high activity Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2
-
Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-1 and its reaction products, detailed overview Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 the enzyme catalyzes the first and rate-limiting step in the oxidative heme breakdown, physiological role of isozyme HO-2 and its reaction products, detailed overview Homo sapiens biliverdin + Fe2+ + CO + A + H2O
-
?

Synonyms

Synonyms Comment Organism
HO-1
-
Homo sapiens
HO-1
-
Mus musculus
HO-2
-
Mus musculus
HO-2
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
-
Homo sapiens additional information
additional information
-
-
Mus musculus additional information