Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride | IC50: 0.00006 mM | Rattus norvegicus | |
(+-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride | IC50: 0.0062 mM | Rattus norvegicus | |
(+-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | IC50: 0.00014 mM | Rattus norvegicus | |
(+-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | IC50: 0.0005 mM | Rattus norvegicus | |
(+-)-4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | IC50: 0.0014 mM | Rattus norvegicus | |
(+/-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride | - |
Rattus norvegicus | |
(+/-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride | - |
Rattus norvegicus | |
(+/-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | - |
Rattus norvegicus | |
(+/-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | - |
Rattus norvegicus | |
1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | IC50: 0.0019 mM | Rattus norvegicus | |
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | IC50: 0.0043 mM | Rattus norvegicus | |
1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | IC50: 0.0038 mM | Rattus norvegicus | |
1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | IC50: 0.0037 mM | Rattus norvegicus | |
1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | IC50: 0.0007 mM | Rattus norvegicus | |
1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone hydrochloride | IC50: 0.00011 mM | Rattus norvegicus | |
1-(1H-imidazol-1-yl)-4-phenyl-2-butanone hydrochloride | IC50: 0.004 mM | Rattus norvegicus | |
2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes | - |
Rattus norvegicus | |
4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | IC50: 0.0017 mM | Rattus norvegicus | |
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | IC50: 0.0047 mM | Rattus norvegicus | |
4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | IC50: 0.0027 mM | Rattus norvegicus | |
azalanstat | IC50: 0.0053 mM | Rattus norvegicus | |
additional information | synthesis of a series of 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes comprising imidazole-ketones, imidazole-dioxolanes, and imidazole-alcohols substituted with halogens in the phenyl ring, evaluation of the inhibitory potency on heme oxygenase, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Rattus norvegicus | - |
biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
constitutive isozyme HO-2 | - |
Rattus norvegicus | - |
inducible isozyme HO-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | isozyme HO-2 | Rattus norvegicus | - |
spleen | - |
Rattus norvegicus | - |
spleen | isozyme HO-1 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + electron donor + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Rattus norvegicus |
heme oxygenase-2 | - |
Rattus norvegicus |
HO-1 | - |
Rattus norvegicus |
HO-2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00006 | - |
IC50: 0.00006 mM | Rattus norvegicus | (+-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride | |
0.00011 | - |
IC50: 0.00011 mM | Rattus norvegicus | 1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone hydrochloride | |
0.00014 | - |
IC50: 0.00014 mM | Rattus norvegicus | (+-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
0.0005 | - |
IC50: 0.0005 mM | Rattus norvegicus | (+-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
0.0007 | - |
IC50: 0.0007 mM | Rattus norvegicus | 1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
0.0014 | - |
IC50: 0.0014 mM | Rattus norvegicus | (+-)-4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
0.0017 | - |
IC50: 0.0017 mM | Rattus norvegicus | 4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
0.0019 | - |
IC50: 0.0019 mM | Rattus norvegicus | 1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
0.0027 | - |
IC50: 0.0027 mM | Rattus norvegicus | 4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
0.0037 | - |
IC50: 0.0037 mM | Rattus norvegicus | 1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
0.0038 | - |
IC50: 0.0038 mM | Rattus norvegicus | 1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
0.004 | - |
IC50: 0.004 mM | Rattus norvegicus | 1-(1H-imidazol-1-yl)-4-phenyl-2-butanone hydrochloride | |
0.0043 | - |
IC50: 0.0043 mM | Rattus norvegicus | 1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
0.0047 | - |
IC50: 0.0047 mM | Rattus norvegicus | 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
0.0053 | - |
IC50: 0.0053 mM | Rattus norvegicus | azalanstat | |
0.0062 | - |
IC50: 0.0062 mM | Rattus norvegicus | (+-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride | |
0.06 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | (+/-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride | |
0.11 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone hydrochloride | |
0.14 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | (+/-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
0.5 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | (+/-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
0.7 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
1.4 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
1.7 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
1.8 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanone hydrochloride | |
1.8 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | (+/-)-1-(1H-imidazol-1-yl)-4-(4-iodophenyl)-2-butanol hydrochloride | |
1.9 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
1.9 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
2.6 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | (+/-)-4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
2.7 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 4-(4-fluorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
3.7 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
3.8 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
4 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | (+/-)-4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol hydrochloride | |
4 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-(1H-imidazol-1-yl)-4-phenyl-2-butanone hydrochloride | |
4.3 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
4.7 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
5.3 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | azalanstat | |
6.2 | - |
pH 7.4, 37°C, spleen isozyme HO-1 | Rattus norvegicus | (+/-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride | |
9.5 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 4-(4-bromophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
11.3 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-(1H-imidazol-1-yl)-4-phenyl-2-butanone hydrochloride | |
16 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | (+/-)-1-(1H-imidazol-1-yl)-4-phenyl-2-butanol hydrochloride | |
17.9 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
24.5 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | azalanstat | |
43.1 | - |
pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone hydrochloride | |
100 | - |
above, pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
100 | - |
above, pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-((2-(2-phenylethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
100 | - |
above, pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-((2-(2-(4-fluorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
100 | - |
above, pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-((2-(2-(4-bromophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | |
100 | - |
above, pH 7.4, 37°C, brain isozyme HO-2 | Rattus norvegicus | 1-((2-(2-(4-iodophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride |