Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.14.18 extracted from

  • Zhang, X.; Fujii, H.; Matera, K.M.; Migita, C.T.; Sun, D.; Sato, M.; Ikeda-Saito, M.; Yoshida, T.
    Stereoselectivity of each of the three steps of the heme oxygenase reaction: Hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin (2003), Biochemistry, 42, 7418-7426.
    View publication on PubMed
Search for more literature for 1.14.14.18

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 truncated, soluble form
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXalpha + CO + acceptor + H2O
-
 ?
beta-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXbeta + CO + acceptor + H2O
-
 ?
delta-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXdelta + CO + acceptor + H2O
-
 ?
gamma-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXgamma + CO + acceptor + H2O
-
 ?
hemin + reduced acceptor + O2
-
 Rattus norvegicus alpha-meso-hydroxyhemin IX + CO + acceptor + H2O
-
 ?
additional information reaction proceeds via three steps, first step is alpha-regioselective hydroxylation of hemin, second degradation of meso-hydroxyhemin to verdoheme and third degradation of verdoheme to biliverdin, which again is stereoselective for verdoheme IXalpha. In the second step, enzyme would convert all four isomers of meso-hydroxyhemin Rattus norvegicus ?
-
 ?
verdoheme IXalpha + H2O
-
 Rattus norvegicus biliverdin IXalpha + Fe2+
-
 ?