Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | weak | Bos taurus | |
1,10-phenanthroline | weak | Gallus gallus | |
1,10-phenanthroline | weak | Homo sapiens | |
1,10-phenanthroline | weak | Oryctolagus cuniculus | |
1,10-phenanthroline | weak | Rattus norvegicus | |
1,10-phenanthroline | weak | Sus scrofa | |
2,2'-dipyridyl | weak | Bos taurus | |
2,2'-dipyridyl | weak | Gallus gallus | |
2,2'-dipyridyl | weak | Homo sapiens | |
2,2'-dipyridyl | weak | Oryctolagus cuniculus | |
2,2'-dipyridyl | weak | Rattus norvegicus | |
2,2'-dipyridyl | weak | Sus scrofa | |
4-hydroxymercuribenzoate | - |
Bos taurus | |
4-hydroxymercuribenzoate | - |
Gallus gallus | |
4-hydroxymercuribenzoate | - |
Homo sapiens | |
4-hydroxymercuribenzoate | - |
Oryctolagus cuniculus | |
4-hydroxymercuribenzoate | - |
Rattus norvegicus | |
4-hydroxymercuribenzoate | - |
Sus scrofa | |
CO | strong inhibition | Bos taurus | |
CO | strong inhibition | Gallus gallus | |
CO | strong inhibition | Homo sapiens | |
CO | strong inhibition | Oryctolagus cuniculus | |
CO | strong inhibition | Rattus norvegicus | |
CO | strong inhibition | Sus scrofa | |
Co2+ | 0.4 mM, significant inhibition | Bos taurus | |
Co2+ | 0.4 mM, significant inhibition | Gallus gallus | |
Co2+ | 0.4 mM, significant inhibition | Homo sapiens | |
Co2+ | 0.4 mM, significant inhibition | Oryctolagus cuniculus | |
Co2+ | 0.4 mM, significant inhibition | Rattus norvegicus | |
Co2+ | 0.4 mM, significant inhibition | Sus scrofa | |
Cu2+ | 0.2 mM, significant inhibition | Bos taurus | |
Cu2+ | 0.2 mM, significant inhibition | Gallus gallus | |
Cu2+ | 0.2 mM, significant inhibition | Homo sapiens | |
Cu2+ | 0.2 mM, significant inhibition | Oryctolagus cuniculus | |
Cu2+ | 0.2 mM, significant inhibition | Rattus norvegicus | |
Cu2+ | 0.2 mM, significant inhibition | Sus scrofa | |
cysteine | - |
Bos taurus | |
cysteine | - |
Gallus gallus | |
cysteine | - |
Homo sapiens | |
cysteine | - |
Oryctolagus cuniculus | |
cysteine | - |
Rattus norvegicus | |
cysteine | - |
Sus scrofa | |
EDTA | weak | Bos taurus | |
EDTA | weak | Gallus gallus | |
EDTA | weak | Homo sapiens | |
EDTA | weak | Oryctolagus cuniculus | |
EDTA | weak | Rattus norvegicus | |
EDTA | weak | Sus scrofa | |
KCN | strong inhibition | Bos taurus | |
KCN | strong inhibition | Gallus gallus | |
KCN | strong inhibition | Homo sapiens | |
KCN | strong inhibition | Oryctolagus cuniculus | |
KCN | strong inhibition | Rattus norvegicus | |
KCN | strong inhibition | Sus scrofa | |
NaN3 | strong inhibition | Bos taurus | |
NaN3 | strong inhibition | Gallus gallus | |
NaN3 | strong inhibition | Homo sapiens | |
NaN3 | strong inhibition | Oryctolagus cuniculus | |
NaN3 | strong inhibition | Rattus norvegicus | |
NaN3 | strong inhibition | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
protoheme IX | enzyme from spleen and liver | Rattus norvegicus | |
0.0164 | - |
protoheme IX | enzyme from spleen | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Gallus gallus | - |
- |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Sus scrofa | - |
- |
microsome | - |
Bos taurus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
200000 | - |
gel filtration | Rattus norvegicus |
200000 | - |
gel filtration | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + 2 NADPH + 2 H+ + 2 O2 | Gallus gallus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | Homo sapiens | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | Rattus norvegicus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | Sus scrofa | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | Bos taurus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | Oryctolagus cuniculus | involved in heme metabolism | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Gallus gallus | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
brain | - |
Sus scrofa | - |
brain | - |
Bos taurus | - |
brain | - |
Oryctolagus cuniculus | - |
heart | - |
Gallus gallus | - |
heart | - |
Homo sapiens | - |
heart | - |
Rattus norvegicus | - |
heart | - |
Sus scrofa | - |
heart | - |
Bos taurus | - |
heart | - |
Oryctolagus cuniculus | - |
kidney | - |
Gallus gallus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Sus scrofa | - |
kidney | - |
Bos taurus | - |
kidney | - |
Oryctolagus cuniculus | - |
liver | - |
Gallus gallus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
liver | - |
Bos taurus | - |
liver | - |
Oryctolagus cuniculus | - |
lung | - |
Gallus gallus | - |
lung | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Sus scrofa | - |
lung | - |
Bos taurus | - |
lung | - |
Oryctolagus cuniculus | - |
macrophage | peritoneal, alveolar | Gallus gallus | - |
macrophage | peritoneal, alveolar | Homo sapiens | - |
macrophage | peritoneal, alveolar | Rattus norvegicus | - |
macrophage | peritoneal, alveolar | Sus scrofa | - |
macrophage | peritoneal, alveolar | Bos taurus | - |
macrophage | peritoneal, alveolar | Oryctolagus cuniculus | - |
marrow | - |
Gallus gallus | - |
marrow | - |
Homo sapiens | - |
marrow | - |
Rattus norvegicus | - |
marrow | - |
Sus scrofa | - |
marrow | - |
Bos taurus | - |
marrow | - |
Oryctolagus cuniculus | - |
small intestine mucosa | - |
Gallus gallus | - |
small intestine mucosa | - |
Homo sapiens | - |
small intestine mucosa | - |
Rattus norvegicus | - |
small intestine mucosa | - |
Sus scrofa | - |
small intestine mucosa | - |
Bos taurus | - |
small intestine mucosa | - |
Oryctolagus cuniculus | - |
spleen | - |
Gallus gallus | - |
spleen | - |
Homo sapiens | - |
spleen | - |
Rattus norvegicus | - |
spleen | - |
Sus scrofa | - |
spleen | - |
Bos taurus | - |
spleen | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
assay procedure | Gallus gallus |
additional information | - |
assay procedure | Homo sapiens |
additional information | - |
assay procedure | Rattus norvegicus |
additional information | - |
assay procedure | Sus scrofa |
additional information | - |
assay procedure | Bos taurus |
additional information | - |
assay procedure | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Gallus gallus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Homo sapiens | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Rattus norvegicus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Sus scrofa | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Bos taurus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + 2 NADPH + 2 H+ + 2 O2 | involved in heme metabolism | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + 2 NADP+ + H2O | - |
? | |
heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Homo sapiens | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Sus scrofa | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Bos taurus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | iron-protoporphyrin IX is the most active substrate, lower activity with: iron-mesoporphyrin IX, iron-deuteroheme IX, iron-coproheme I, alpha and beta chain of hemoglobin, poor substrates: oxyhemoglobin, carboxyhemoglobin, myoglobin | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Gallus gallus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Homo sapiens | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Rattus norvegicus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Sus scrofa | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Bos taurus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
heme + electron donor + O2 | porphyrins without chelated iron and metalloporphyrins other than iron porphyrins are not oxidized | Oryctolagus cuniculus | biliverdin + Fe2+ + CO + oxidized eletron donor + H2O | - |
? | |
methemoglobin + electron donor + O2 | - |
Gallus gallus | ? | - |
? | |
methemoglobin + electron donor + O2 | - |
Homo sapiens | ? | - |
? | |
methemoglobin + electron donor + O2 | - |
Rattus norvegicus | ? | - |
? | |
methemoglobin + electron donor + O2 | - |
Sus scrofa | ? | - |
? | |
methemoglobin + electron donor + O2 | - |
Bos taurus | ? | - |
? | |
methemoglobin + electron donor + O2 | - |
Oryctolagus cuniculus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Gallus gallus |
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Sus scrofa |
37 | - |
assay at | Bos taurus |
37 | - |
assay at | Oryctolagus cuniculus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
- |
4 | several hours | Gallus gallus |
- |
4 | several hours | Homo sapiens |
- |
4 | several hours | Rattus norvegicus |
- |
4 | several hours | Sus scrofa |
- |
4 | several hours | Bos taurus |
- |
4 | several hours | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Rattus norvegicus |