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Literature summary for 1.14.14.17 extracted from

  • Laden, B.P.; Porter, T.D.
    Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls (2001), J. Lipid Res., 42, 235-240.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dimethyltelluride approx. 0.0001 mM, 50% inhibition of recombinant enzyme, 0.1 mM, complete inhibition, preincubation with 1 mM glutathione maintains 50% of initial activity Homo sapiens
dimethyltellurium dichloride approx. 0.0001 mM, 50% inhibition of recombinant enzyme, 0.1 mM, complete inhibition, preincubation with 1 mM glutathione maintains 50% of initial activity Homo sapiens
Phenylarsine oxide recombinant enzyme, glutathione and 2,3-dimercaptopropanol protect almost completely Homo sapiens
tellurite 0.01 mM, 50% inhibition of recombinant enzyme, 10 mM, 95% inhibition, glutathione and 2,3-dimercaptopropanol protect almost completely Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens