Literature summary for 1.14.14.17 extracted from

Abe, I.; Seki, T.; Noguchi, H.; Kashiwada, Y.
Galloyl esters from rhubarb are potent inhibitors of squalene epoxidase, a key enzyme in cholesterol biosynthesis (2000), Planta Med., 66, 753-756.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
1,2,6-Tri-O-galloyl-beta-D-glucose	0.00063 mM, 50% inhibition	Rattus norvegicus
1,6-di-O-galloyl-2-O-cinnamoyl-beta-D-glucose	0.00058 mM, 50% inhibition	Rattus norvegicus
additional information	cholesterol lowering effect of rhubarb, Rhei Rhizoma, Rheum palmatum L. and polygnaceae, galloyl glucoses and galloyl proanthocyanidins may be attributed to their potent squalene oxidase inhibition	Rattus norvegicus
procyanidin B-2 3,3'-di-O-gallate	0.00054 mM, 50% inhibition	Rattus norvegicus
procyanidin B-5 3,3'-di-O-gallate	0.00055 mM, 50% inhibition	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

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Release 2023.1 (January 2023)