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Literature summary for 1.14.14.14 extracted from

  • Fishman, J.; Goto, J.
    Mechanism of estrogen biosynthesis. Participation of multiple enzyme sites in placental aromatase hydroxylations (1981), J. Biol. Chem., 256, 4466-4471.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
19-hydroxyandrost-4-ene-3,17-dione competitively inhibits the formation of 19-hydroxyandrost-4-ene-3,17-dione and estrogen Homo sapiens
19-oxoandrost-4-ene-3,17-dione competitively inhibits the formation of 19-oxoandrost-4-ene-3,17-dione and estrogen Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
19-hydroxyandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein
-
Homo sapiens 19-oxo-androst-4-ene-3,17-dione + 2 H2O + an oxidized flavoprotein
-
?
19-oxoandrost-4-ene-3,17-dione + O2 + a reduced flavoprotein
-
Homo sapiens estrone + formate + H2O + an oxidized flavoprotein
-
?
androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins
-
Homo sapiens estrone + formate + 4 H2O + 3 oxidized flavoproteins overall reaction ?
androst-4-ene-3,17-dione + O2 + a reduced flavoprotein
-
Homo sapiens 19-hydroxyandrost-4-ene-3,17-dione + H2O + an oxidized flavoprotein
-
?
additional information the aromatization of androstenedione probably involves two successive hydroxylations at the C-19 methyl group, mediated by a common catalytic site with the third and rate-determining 2beta-hydroxylation taking place at a different enzyme site Homo sapiens ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00038
-
19-hydroxyandrost-4-ene-3,17-dione substrate 19-oxoandrost-4-ene-3,17-dione, pH 7.0, 37°C Homo sapiens
0.00045
-
19-hydroxyandrost-4-ene-3,17-dione substrate androst-4-ene-3,17-dione, pH 7.0, 37°C Homo sapiens
0.0015
-
19-oxoandrost-4-ene-3,17-dione substrate 19-hydroxyandrost-4-ene-3,17-dione, pH 7.0, 37°C Homo sapiens
0.003
-
19-oxoandrost-4-ene-3,17-dione substrate androst-4-ene-3,17-dione, pH 7.0, 37°C Homo sapiens