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Literature summary for 1.14.14.1 extracted from

  • Platt, K.L.; Edenharder, R.; Aderhold, S.; Muckel, E.; Glatt, H.
    Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed in immortal mammalian cells (2010), Mutat. Res., 703, 90-98.
    View publication on PubMed
Search for more literature for 1.14.14.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in V79 Chinese hamster fibroblasts and Hep-G2 cells, coexpression with N(O)-acetyltransferase or sulfotransferase 1A1-1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information only sour cherry, blueberry, and black currant juices suppress the first step of xenobiotic enzymatic activation by CYP1A2, whereas most plant-derived beverages, from diverse plants, inhibit the second step catalyzed by other enzymes, relative inhibition rates, detailed overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine + [reduced NADPH-hemoprotein reductase] + O2 CYP1A2 catalyzes the first step of activation of the xenobiotic compound and its genotoxic effect, the second step is catalyzed by the sulfotransferase 1A1-1 Homo sapiens ?
-
 ?
2-amino-3-methylimidazo[4,5-f]quinoline + [reduced NADPH-hemoprotein reductase] + O2 CYP1A2 catalyzes the first step of activation of the xenobiotic compound and its genotoxic effect, the second step is catalyzed by the N(O)-acetyltransferase. Homo sapiens ?
-
 ?
additional information CYP1A2 catalyzes the O-demethylation of 7-methoxyresorufin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP1A2
-
 Homo sapiens
cytochrome P450-dependent monooxygenase 1A2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Homo sapiens