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Literature summary for 1.14.14.1 extracted from

  • Liu, Y.; Glatt, H.
    Human cytochrome P450 2E1 and sulfotransferase 1A1 coexpressed in Chinese hamster V79 cells enhance spontaneous mutagenesis (2010), Environ. Mol. Mutagen., 51, 23-30.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
V79-hCYP2E1 (constructed by transfection of CYP2E1-expressing vector pSV together with vector pSV2neo containing a G418-selective marker into V79-Mz cells) and SULT1A1 expression vector introduced into this cell line Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-aminobenzotriazole moderately prohibits spontaneous mutations of V79-hCYP2E1-hSULT1A1 cells. In combination with SULT1A1 inhibitor pentachlorophenol completely prohibits spontaneous mutations of V79-hCYP2E1-hSULT1A1 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chlorzoxazone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CYP2E1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens V79-hCYP2E1-hSULT1A1 cells contain a higher level of hCYP2E1 protein than the parental V79-hCYP2E1 line (by a factor of 3–4) up

General Information

General Information Comment Organism
physiological function CYP2E1 and sulfotransferase SULT1A1 activate an endogenous cellular molecule or a medium component to become mutagenic Homo sapiens